Protein Alignment UCP2 and CG18418

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_647924.2
• Gene: CG18418 / 38572
• FlyBaseID: FBgn0035568
• Length: 311
• Species: Drosophila melanogaster
• Alignment Length: 302
• Identity: 92/302 - (30%)
• Similarity: 150/302 - (49%)
• Gaps: 18/302 - (5%)

Human     3 GFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTIL 67
            |.:...||  ..:||:..||:..:|..|..|||..|.|:||.|       ...:.:|:.....:.
  Fly     6 GVEKKTVP--THMKFVMGGTSGMLATCIVQPLDLLKTRMQISG-------TLGTREYKNSFEVLS 61

Human    68 TMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKG-SEHASIGSRLLAGSTTGALAV 131
            .:::.||..||||||.|||.||.::.|.::|:|.....:|.|. ..:.|:.:.:..|...||...
  Fly    62 KVLKNEGILSLYNGLSAGLLRQATYTSAKMGVYQMELDWYRKNFGNYPSMVASMTMGIVAGAFGA 126

Human   132 AVAQPTDVVKVRFQAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAEL 194
            ....|.:|..:|..:..|  ....|.|::..:|:..|.::||...||:|..|.|.|..:||..:|
  Fly   127 MCGNPAEVALIRMMSDNRLMPEDRRNYKNVGDAFVRIVKDEGVVALWRGCLPTVGRAMVVNMVQL 191

Human   195 VTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL----GQYSSAGH 255
            .:|.|:|:.|  ...:::.:|.|.|:|..:|..|:|.:.|:|:.|||.....:    .:||....
  Fly   192 ASYSLMKNQL--HGYLSEGIPLHLTAALVSGLLTSVTSMPLDMAKTRIQQMKVIDGKPEYSGTID 254

Human   256 CALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
            ....:|:.||..|.:|||.|..:|:|...:..||..||:.:|
  Fly   255 VLKKVLKNEGAFAVWKGFTPYLMRMGPHTIFSFVFLEQMNKA 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	34/101 (34%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		31/94 (33%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		15/46 (33%)
		transmembrane domain	17..34		5/16 (31%)
		transmembrane domain	78..100		12/21 (57%)
		Mito_carr	112..206	CDD:395101	27/95 (28%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		26/90 (29%)
		transmembrane domain	120..137		3/16 (19%)
		transmembrane domain	174..197		9/22 (41%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		28/88 (32%)
		transmembrane domain	216..235		6/18 (33%)
		Mito_carr	217..299	CDD:395101	28/85 (33%)
		purine nucleotide binding domain	264..273		4/8 (50%)
		transmembrane domain	269..291		8/21 (38%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		2/6 (33%)
CG18418	NP_647924.2	Mito_carr	10..108	CDD:395101	35/106 (33%)
		Mito_carr	109..205	CDD:395101	27/97 (28%)
		Mito_carr	208..300	CDD:395101	29/89 (33%)