Protein Alignment UCP2 and CG7514

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_647923.1
• Gene: CG7514 / 38571
• FlyBaseID: FBgn0035567
• Length: 301
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 89/288 - (30%)
• Similarity: 133/288 - (46%)
• Gaps: 23/288 - (7%)

Human    17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNG 81
            ::..|.|..:...|..|||..|.|:||         :..:.:|:.....:|.:.:.||..:||||
  Fly    16 YINGGLAGMLGTCIVQPLDLVKTRMQI---------SATTGEYKSSFDCLLKVFKNEGILALYNG 71

Human    82 LVAGLQRQMSFASVRIGLYDSV-----KQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVK 141
            |.|||.||.::.:.|:|.|...     |||....:..||:|..:||    ||.......|.:|..
  Fly    72 LSAGLMRQATYTTARMGFYQMEIDAYRKQFNAPPTVLASMGMGILA----GAFGAMFGNPAEVAL 132

Human   142 VRFQAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDAL 204
            :|..:..|  ....|.|...:||:..|.::||...||||..|.|.|..|||..:|.:|..:|.|.
  Fly   133 IRMMSDNRLPPAERRNYTGVLNAFVRIVKDEGVITLWKGCMPTVGRAMIVNMVQLASYSQLKAAF 197

Human   205 LKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAF 269
            .:   ....|..|..:|..:|..||:.:.|:|:.|||.......:|.......:.:.:.||..:.
  Fly   198 SE---YFSGLSLHIAAAMMSGLLTTIASMPLDMAKTRIQQQKTAEYKGTMDVLMKVSKNEGIASL 259

Human   270 YKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
            :|||.|...|||...|..|:..|||.:|
  Fly   260 WKGFTPYLCRLGPHTVFAFIFLEQLTKA 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	30/98 (31%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		28/93 (30%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		11/45 (24%)
		transmembrane domain	17..34		3/16 (19%)
		transmembrane domain	78..100		12/21 (57%)
		Mito_carr	112..206	CDD:395101	32/95 (34%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		31/90 (34%)
		transmembrane domain	120..137		4/16 (25%)
		transmembrane domain	174..197		11/22 (50%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		26/84 (31%)
		transmembrane domain	216..235		5/18 (28%)
		Mito_carr	217..299	CDD:395101	26/81 (32%)
		purine nucleotide binding domain	264..273		3/8 (38%)
		transmembrane domain	269..291		9/21 (43%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		3/6 (50%)
CG7514	NP_647923.1	Mito_carr	19..90	CDD:395101	26/79 (33%)
		Mito_carr	104..201	CDD:395101	32/103 (31%)
		Mito_carr	207..284	CDD:395101	23/76 (30%)