Protein Alignment UCP2 and Shawn

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_001027071.1
• Gene: Shawn / 3772641
• FlyBaseID: FBgn0031039
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 347
• Identity: 73/347 - (21%)
• Similarity: 127/347 - (36%)
• Gaps: 71/347 - (20%)

Human     5 KATDVPPTATVKFLGAGTAACIADLIT----FPLDTAKVRLQIQ--------------------- 44
            |||...|...::.|....:||...::|    .|||..|.|||.|
  Fly    27 KATMTDPRFRIRPLQQVASACTGAMVTACFMTPLDVIKTRLQAQQQALLSNKCFLYCNGLMDHIC 91

Human    45 ---GESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQF 106
               .::..|..|..:.::.|.:...:.:.||||..||::||...|...:....:....|:..|..
  Fly    92 PCGPDTPNPAAAKPAPRFSGTIDAFIKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKAR 156

Human   107 YTKGSEHASIGSR-----------------LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR 154
            :|  ..|.....|                 ||||.:...|||....|.::::.:.|:|...
  Fly   157 FT--DIHYKYTRRPDTIAHDIPHPIPFLVPLLAGVSGRILAVTCVSPVELIRTKMQSQRMT---- 215

Human   155 RYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFT 219
             :.......:.:.:.:|..|||:|..|.:.|:...:......|:     .||::....:....|:
  Fly   216 -HAEMFGTIRQVVQSQGVLGLWRGLPPTILRDVPFSGIYWTCYE-----YLKSSFGVVEPTFSFS 274

Human   220 SAFGA--GFCTTVIASPVDVVKTR----------YMNSALGQYS--SAGHCALTMLQKEGPRAFY 270
            .|.||  |.....|.:|.|||||.          :.::...|.:  |......::.:..|..|.:
  Fly   275 FAAGAISGSVAATITTPFDVVKTHEQIEFGEKFIFSDNPPKQVATKSVAMRLASIYRMGGVPAIF 339

Human   271 KGFMPSFLRLGSWNVVMFVTYE 292
            .|..|...::.....:|..::|
  Fly   340 SGLGPRLFKVAPACAIMISSFE 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	28/128 (22%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		27/122 (22%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		15/74 (20%)
		transmembrane domain	17..34		4/20 (20%)
		transmembrane domain	78..100		4/21 (19%)
		Mito_carr	112..206	CDD:395101	20/110 (18%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		19/105 (18%)
		transmembrane domain	120..137		7/16 (44%)
		transmembrane domain	174..197		6/22 (27%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		20/95 (21%)
		transmembrane domain	216..235		6/20 (30%)
		Mito_carr	217..299	CDD:395101	20/90 (22%)
		purine nucleotide binding domain	264..273		2/8 (25%)
		transmembrane domain	269..291		3/21 (14%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		0/6 (0%)
Shawn	NP_001027071.1	Mito_carr	39..159	CDD:395101	27/121 (22%)
		Mito_carr	178..265	CDD:395101	20/96 (21%)
		Mito_carr	268..371	CDD:395101	20/94 (21%)