Protein Alignment UCP2 and CG18324

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_725361.1
• Gene: CG18324 / 36568
• FlyBaseID: FBgn0033905
• Length: 307
• Species: Drosophila melanogaster
• Alignment Length: 290
• Identity: 79/290 - (27%)
• Similarity: 127/290 - (43%)
• Gaps: 14/290 - (4%)

Human    17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNG 81
            |:..||||..|.:.|.|:|..|.|:|:|||.  ..|.|....||.:...:|.:|..:|..:|..|
  Fly     6 FVLGGTAAMGAVVFTNPIDVVKTRMQLQGEL--AARGTYVKPYRHLPQAMLQIVLNDGLLALEKG 68

Human    82 LVAGLQRQMSFASVRIGLYDSVKQF-YTKGSEHA-SIGSRLLAGSTTGALAVAVAQPTDVVKVRF 144
            |...|..|....|||:.:|.:..:. |.:.::.: |....:..|:..|......|.|..::|.:.
  Fly    69 LAPALCYQFVLNSVRLSVYSNALELGYLQNADGSISFYRGMFFGALGGCTGTYFASPFYMIKAQQ 133

Human   145 QAQA----RAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALL 205
            .|||    ..|...::.|.::|...|.|..|..|.|:...|::.|..:.:..::.|:...|..|.
  Fly   134 HAQAVQSIAVGFQHKHTSMMDALLHIYRTNGISGFWRAALPSLNRTLVASSVQIGTFPKAKSLLK 198

Human   206 KANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQ------YSSAGHCALTMLQKE 264
            ....:|..:...|.:...:|....|..||.||:.||..|..:.:      |.....|...:.:.|
  Fly   199 DKGWITHPVLLSFCAGLSSGTLVAVANSPFDVLTTRMYNQPVDEKGRGLMYKGLVDCFTKIWRTE 263

Human   265 GPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294
            |....||||.|.:.|......:.||.:|:|
  Fly   264 GIHGMYKGFWPIYFRSAPHTTLTFVFFEKL 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	32/94 (34%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		31/88 (35%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		19/45 (42%)
		transmembrane domain	17..34		7/16 (44%)
		transmembrane domain	78..100		8/21 (38%)
		Mito_carr	112..206	CDD:395101	22/98 (22%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		21/93 (23%)
		transmembrane domain	120..137		3/16 (19%)
		transmembrane domain	174..197		4/22 (18%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		24/89 (27%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	24/84 (29%)
		purine nucleotide binding domain	264..273		4/8 (50%)
		transmembrane domain	269..291		8/21 (38%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		1/6 (17%)
CG18324	NP_725361.1	Mito_carr	4..87	CDD:395101	30/82 (37%)
		Mito_carr	101..201	CDD:395101	22/99 (22%)
		Mito_carr	204..296	CDD:395101	25/90 (28%)