Protein Alignment UCP2 and Ucp4C

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_608976.1
• Gene: Ucp4C / 33832
• FlyBaseID: FBgn0031757
• Length: 335
• Species: Drosophila melanogaster
• Alignment Length: 316
• Identity: 101/316 - (31%)
• Similarity: 160/316 - (50%)
• Gaps: 32/316 - (10%)

Human     4 FKATDVPPTATVK---------FLGAGTA-ACIADLITFPLDTAKVRLQIQGESQGPVRATASAQ 58
            |..|:|....|.:         |:||..| :|:     ||||.||.|:|:.|| |......|...
  Fly    22 FPPTNVADPLTARNLFQLYVNTFIGANLAESCV-----FPLDVAKTRMQVDGE-QAKKTGKAMPT 80

Human    59 YRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY----TKGSEHASIGSR 119
            :|   .|:..|:|.||.:|||.|..|.:.|...|.|:|:.|||..::.:    .:..|...|...
  Fly    81 FR---ATLTNMIRVEGFKSLYAGFSAMVTRNFIFNSLRVVLYDVFRRPFLYQNERNEEVLKIYMA 142

Human   120 LLAGSTTGALAVAVAQPTDVVKVRFQAQAR---AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSP 181
            |....|.|.:|.|:|.|.|:||||.|.:.|   .|...|..|.|.|:..|.|..|...:|||..|
  Fly   143 LGCSFTAGCIAQALANPFDIVKVRMQTEGRRRQLGYDVRVNSMVQAFVDIYRRGGLPSMWKGVGP 207

Human   182 NVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA 246
            :..|..::...::.:||:.|....:...:.:.||..|.|:..||...:|:::|.||:|:|.||..
  Fly   208 SCMRACLMTTGDVGSYDISKRTFKRLLDLEEGLPLRFVSSMCAGLTASVLSTPADVIKSRMMNQP 272

Human   247 LGQ------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
            :.:      |.::..|...::::||....|||.||::.|||.::|:.:::.|||::
  Fly   273 VDESGKNLYYKNSLDCVRKLVREEGVLTLYKGLMPTWFRLGPFSVLFWLSVEQLRQ 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	36/114 (32%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		36/104 (35%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		18/56 (32%)
		transmembrane domain	17..34		6/17 (35%)
		transmembrane domain	78..100		8/21 (38%)
		Mito_carr	112..206	CDD:395101	32/96 (33%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		31/91 (34%)
		transmembrane domain	120..137		6/16 (38%)
		transmembrane domain	174..197		5/22 (23%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		30/91 (33%)
		transmembrane domain	216..235		5/18 (28%)
		Mito_carr	217..299	CDD:395101	28/86 (33%)
		purine nucleotide binding domain	264..273		4/8 (50%)
		transmembrane domain	269..291		9/21 (43%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		3/6 (50%)
Ucp4C	NP_608976.1	Mito_carr	49..124	CDD:395101	32/83 (39%)
		Mito_carr	137..232	CDD:395101	31/94 (33%)
		Mito_carr	237..329	CDD:395101	30/92 (33%)