Protein Alignment UCHL1 and YUH1

DIOPT Version :10

• Sequence 1: NP_004172.2
• Gene: UCHL1 / 7345
• HGNCID: 12513
• Length: 223
• Species: Homo sapiens
• Sequence 2: NP_012633.1
• Gene: YUH1 / 853562
• SGDID: S000003860
• Length: 236
• Species: Saccharomyces cerevisiae
• Alignment Length: 235
• Identity: 65/235 - (27%)
• Similarity: 115/235 - (48%)
• Gaps: 33/235 - (14%)

Human     5 PMEINPEMLNKVLSRLGVAGQWRFVDVLGL-EEESLGSVPAPACALLLLFPLTAQHENFRKKQIE 68
            |:|.|||:......:||:..:|.:.|:..| |.|.|..:|.|..|::||||:....::...:||.
Yeast    10 PIESNPEVFTNFAHKLGLKNEWAYFDIYSLTEPELLAFLPRPVKAIVLLFPINEDRKSSTSQQIT 74

Human    69 ELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFL-SETEKMSPEDRAKC 132
            .      |..|.:.||::.|:||...::|:::|||..|  |.||.|..|| |:::..|.::|
Yeast    75 S------SYDVIWFKQSVKNACGLYAILHSLSNNQSLL--EPGSDLDNFLKSQSDTSSSKNR--- 128

Human   133 FEK-----------NEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGR-MPFPVNH 185
            |:.           .|.:|......::..:...|  .|.|:|.:...:|.::||||| :..|:..
Yeast   129 FDDVTTDQFVLNVIKENVQTFSTGQSEAPEATAD--TNLHYITYVEENGGIFELDGRNLSGPLYL 191

Human   186 GAS---SEDTLLKDAAKV-CREFTE--REQGEVRFSAVAL 219
            |.|   :.|.:.::..:| ...:.|  .|:..:.|:.:.|
Yeast   192 GKSDPTATDLIEQELVRVRVASYMENANEEDVLNFAMLGL 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCHL1	NP_004172.2	Peptidase_C12_UCH_L1_L3	5..219	CDD:187737	64/233 (27%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	5..10		2/4 (50%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	211..216		1/4 (25%)
YUH1	NP_012633.1	Peptidase_C12	8..231	CDD:471809	64/233 (27%)