Protein Alignment UCHL1 and Uch

DIOPT Version :10

• Sequence 1: NP_004172.2
• Gene: UCHL1 / 7345
• HGNCID: 12513
• Length: 223
• Species: Homo sapiens
• Sequence 2: NP_476940.1
• Gene: Uch / 33397
• FlyBaseID: FBgn0010288
• Length: 227
• Species: Drosophila melanogaster
• Alignment Length: 222
• Identity: 102/222 - (45%)
• Similarity: 149/222 - (67%)
• Gaps: 6/222 - (2%)

Human     5 PMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEE 69
            |:|.|||:|.|.:.:|||:..|...||:|||:::|..:|.|..|.:||||.:..:|..|.::.:.
  Fly     6 PLESNPEVLTKYIHKLGVSPAWSVTDVIGLEDDTLEWIPRPVKAFILLFPCSETYEKHRAEEHDR 70

Human    70 LKG-QEVSPK-VYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKC 132
            :|. :|..|: :::|:|...|:|||:.|||:||||:: :..:.| |||.||.:|..:|||:|.:.
  Fly    71 IKEVEEQHPEDLFYMRQFTHNACGTVALIHSVANNKE-VDIDRG-VLKDFLEKTASLSPEERGRA 133

Human   133 FEKNEAIQAAHDAVAQEGQCRV--DDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLK 195
            .||:|...|.|:|:|||||...  .:||..|||...|.:|.|||||||..||:.||.:||:|.:|
  Fly   134 LEKDEKFTADHEALAQEGQTNAANHEKVIHHFIALVNKEGTLYELDGRKSFPIKHGPTSEETFVK 198

Human   196 DAAKVCREFTEREQGEVRFSAVALCKA 222
            ||||||:||..|:..||||:.:||..|
  Fly   199 DAAKVCKEFMARDPNEVRFTVLALTAA 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCHL1	NP_004172.2	Peptidase_C12_UCH_L1_L3	5..219	CDD:187737	99/217 (46%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	5..10		2/4 (50%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	211..216		4/4 (100%)
Uch	NP_476940.1	Peptidase_C12_UCH_L1_L3	4..222	CDD:187737	99/217 (46%)