Protein Alignment UCHL1 and ubh-3

DIOPT Version :10

• Sequence 1: NP_004172.2
• Gene: UCHL1 / 7345
• HGNCID: 12513
• Length: 223
• Species: Homo sapiens
• Sequence 2: NP_504653.2
• Gene: ubh-3 / 259626
• WormBaseID: WBGene00006723
• Length: 227
• Species: Caenorhabditis elegans
• Alignment Length: 218
• Identity: 80/218 - (36%)
• Similarity: 125/218 - (57%)
• Gaps: 9/218 - (4%)

Human     6 MEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEEL 70
            :|.|||.:|..|.::|:.| ...|||...::|.|..||.|..||:|.|| :|:...|..||.||:
 Worm    12 LESNPETINPFLKKIGITG-LECVDVYSFDDEMLQFVPTPQLALILCFP-SAEAREFLSKQYEEV 74

Human    71 KGQEVSPK-VYFMKQT--IGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPED-RAK 131
            :.....|: |:||.|:  |||:|||..|.|::||.::::....|...|.:  |..|:..|| |:.
 Worm    75 EKNGEKPEGVFFMNQSEEIGNACGTFALFHSLANLENRVNLGKGKFAKWY--EKAKLVNEDERSD 137

Human   132 CFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKD 196
            ....:..:..||:..|:||:....|.|::|||.:.|.:|.|||:|...|||...||:::.|::||
 Worm   138 LLSGDTDLAEAHEETAEEGETEQSDHVDYHFITYVNKNGQLYEIDSCAPFPRPLGATTDSTMIKD 202

Human   197 AAKVCREFTEREQGEVRFSAVAL 219
            |:...:|.....: .:.|||:||
 Worm   203 ASTAIKELMNNVK-NLSFSAMAL 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCHL1	NP_004172.2	Peptidase_C12_UCH_L1_L3	5..219	CDD:187737	78/216 (36%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	5..10		1/3 (33%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	211..216		1/4 (25%)
ubh-3	NP_504653.2	Peptidase_C12_UCH_L1_L3	9..224	CDD:187737	78/216 (36%)