Protein Alignment UCHL1 and uch1

DIOPT Version :10

• Sequence 1: NP_004172.2
• Gene: UCHL1 / 7345
• HGNCID: 12513
• Length: 223
• Species: Homo sapiens
• Sequence 2: NP_594531.1
• Gene: uch1 / 2541733
• PomBaseID: SPAC27F1.03C
• Length: 222
• Species: Schizosaccharomyces pombe
• Alignment Length: 229
• Identity: 76/229 - (33%)
• Similarity: 109/229 - (47%)
• Gaps: 25/229 - (10%)

Human     4 KPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIE 68
            :|:|..||:|...|.::||.....| |:..|||.. ..:|.|..|||.:||.:.....:
pombe     3 RPLENTPEVLEPYLQKIGVQDASVF-DLFSLEEIP-EYIPRPVHALLFVFPSSGTKTIY------ 59

Human    69 ELKGQEVSP----KVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDR 129
              ||..:.|    ||.:..|||.|:||||||:|||:|.:.:....:...:|..:...|..|.|:|
pombe    60 --KGSRILPKDSDKVLWYPQTIPNACGTIGLLHAVSNGELRRKVNENDFIKSLIRTAEGSSIEER 122

Human   130 AKCFEKNEAIQAAHDAVA-----QEGQCRVDDKVNFHFILF----NNVDGHLYELDGRMPFPVNH 185
            ||..|.::.::|.|.|.|     .||. ..|.:.:.|||.|    :..|.|.||||||...||.|
pombe   123 AKLIEDSKELEALHAAFAGPPLEVEGS-EEDVETDLHFICFVKGKSKDDNHFYELDGRQEGPVQH 186

Human   186 GASSEDTLLKDAAKVCREFTEREQGEVRFSAVAL 219
            .....|.|..:...|.:.:.:...... ||.||:
pombe   187 SEIESDLLNAEVLSVIKNYIQSIDSPF-FSLVAI 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCHL1	NP_004172.2	Peptidase_C12_UCH_L1_L3	5..219	CDD:187737	75/226 (33%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	5..10		2/4 (50%)
		Interaction with ubiquitin. /evidence=ECO:0000269|PubMed:20439756	211..216		1/4 (25%)
uch1	NP_594531.1	Peptidase_C12_UCH_L1_L3	2..219	CDD:187737	75/227 (33%)