DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UBE3A and HUL4

DIOPT Version :9

Sequence 1:	NP_000453.2	Gene:	UBE3A / 7337	HGNCID:	12496	Length:	875	Species:	Homo sapiens
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	826	Identity:	223/826 - (26%)
Similarity:	369/826 - (44%)	Gaps:	186/826 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   196 AACSAAAMEEDSE-----ASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETA 255
            :||....:.::.|     .||:.|..:.:|...:.:...||:.      |...|.:|..|:....
Yeast   103 SACQVTVIVKEPEINSNLESSTHISCTLEGLQMVVRRCHDDLQ------RLKKTGILDKERKGLI 161

Human   256 FLNALVYLSPNVECDLTYHNVYSRDPNYL------NL----------FIIVMENRNLHSPEYLEM 304
            |...:.||...      :|:|...:.::|      |:          |..::.|.....|.|
Yeast   162 FQPVITYLLDR------FHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYY--- 217

Human   305 ALPLFCKAMSKLPLAAQGKLIRL----W-------------------SK--YNADQIRRM----- 339
            ::...|..:.|.....:|:.:::    |                   ||  :...|||.:
Yeast   218 SMLCCCNDLLKRITINKGENLQILQYRWLLIILNIPTIRTCLIRDRKSKNVFETQQIRAVSYELA 282

Human   340 -----------METFQQLI-----------TYKV--------------ISNEFNSR---NLVNDD 365
                       .:|.||||           :|:|              :|||.::|   |.|..:
Yeast   283 KRCIGYLSNLSTKTSQQLIQSLRRTPTDNFSYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPE 347

Human   366 D--------------------AIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQ 410
            |                    .|.|.|...:...:.:.|..::.....:.:::..|..:::||..
Yeast   348 DEMRSRLRRHHTTGHEFLSTRPISAQSNDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFI 412

Human   411 ELLGEERRNKKGPRVDPLETELGVK-----TLDCRKPLIPFEEFINE--------PLNEVLEMDK 462
            ..:...|||.:|        .|.::     |||    .|.:::..:.        .:|:::|...
Yeast   413 YYVANTRRNGRG--------ALSIQSFYNITLD----FIDYKQDFDHWRGVAQKTKMNQLIEEWG 465

Human   463 DYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKV 527
            :.|     |:..|||...||||:...|...:.|:.|..|..|.....|.||.:|:.::.|.::||
Yeast   466 NST-----TKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKV 525

Human   528 RRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY 592
            |||.|..|:|..::    |:..||.|.|.:||..|.|:|.||:.||:|.|:.:.:|||..|:|.|
Yeast   526 RRDVISHDSLRCIK----EHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIY 586

Human   593 DESTKLFWF--NPSSFE-TEGQ------FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTF 648
            .:.:...||  :|.:|: ::|:      :.|.|:|:||||:|:.|||:.||..:|:||..:..:|
Yeast   587 IKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSF 651

Human   649 RDLGDSHPVLYQSLKDLLEY-EGNVEDDMMITFQISQTDLFGNPMMYDLK-----------ENGD 701
            .|..:..|...::|..:|.| |.|.||...:||:.:..:  .|.::.|.|           |||.
Yeast   652 EDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRN--NNWILNDSKSSKEYVTVELCENGR 714

Human   702 KIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSR--- 763
            .:|||..|:.|||..:.::.|.||:|.|:..|..||..|..|.....||..||:|.|:||..
Yeast   715 NVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

Human   764 NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIA 828
            ..||::|...|:|.||::.||..:..||||:.|:....::..|||.|.:||.|..|:..:...|:
Yeast   780 KFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKIS 844

Human   829 KNGP-DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 873
            ..|. |::.||.:|||||.:.|..||||:||:.:||.||..::|:|
Yeast   845 LLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGYG 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862
UBE3A	NP_000453.2	HECTc	523..873	CDD:238033	138/374 (37%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	223/826 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I708
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53079
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810