DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UBE3A and ube3a

DIOPT Version :9

Sequence 1:	NP_000453.2	Gene:	UBE3A / 7337	HGNCID:	12496	Length:	875	Species:	Homo sapiens
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	857	Identity:	740/857 - (86%)
Similarity:	796/857 - (92%)	Gaps:	5/857 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    24 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPS 88
            |||||||||||||||||||||||||||||.|.|.|.|.||||||||||||||||.||||||||||
Zfish     1 MKRAAAKHLIERYYHQLTEGCGNEACTNEACGSSPGFQRMDNNAAAIKALELYKNNAKLCDPHPS 65

Human    89 KKGASSAYLENS-KGAPN-NSCSEIKMNKKG---ARIDFKDVTYLTEEKVYEILELCREREDYSP 148
            |||||||:.||| |||.| ::||..|||.|.   .|.||:|:.:|||:||||||.:|.|.|||||
Zfish    66 KKGASSAFPENSAKGAHNFSACSNGKMNHKDLPPTREDFRDLNFLTEDKVYEILSICSETEDYSP 130

Human   149 LIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSR 213
            |||||||||||||:|||||||.||||||||||||||||||||||||.|:.|:.|||.:.|||:|.
Zfish   131 LIRVIGRVFSSAESLVQSFRKAKQHTKEELKSLQAKDEDKDEDEKETASGSSTAMEVEPEASASS 195

Human   214 IGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYS 278
            ...||.|:||:|||||.:|||||||:||||.|||||||||.|||||||||||||||||||||||:
Zfish   196 GDGSSHGENNVQKLGPVEVSVDIDAVRRVYDRLLSNEKIEAAFLNALVYLSPNVECDLTYHNVYA 260

Human   279 RDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETF 343
            .||||||:|||||||.|||||||||:|||.||||||||||.|..||.||||:|..|||||::|||
Zfish   261 ADPNYLNVFIIVMENSNLHSPEYLEIALPQFCKAMSKLPLPALAKLARLWSQYGVDQIRRLVETF 325

Human   344 QQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELT 408
            ||||||.||||||:|.||||:||.:|||:||||:||||||:||::||:||||||:||||||||||
Zfish   326 QQLITYTVISNEFSSDNLVNEDDGVVAATKCLKIVYYANVLGGDLDTDHNEEDDDEPIPESSELT 390

Human   409 LQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETEN 473
            |||||||||||||||||||||||:|::..|||||||||||||||||||||||||||||||||||:
Zfish   391 LQELLGEERRNKKGPRVDPLETEMGIRASDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETES 455

Human   474 KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALV 538
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Zfish   456 KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITALYSLVQGQQLNPYLRLKVRRDHIIDDALV 520

Human   539 RLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNP 603
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   521 RLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNP 585

Human   604 SSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY 668
            ||||.||||||||||||||||||||||||||||:||||||||||||||.||||||:||||||:||
Zfish   586 SSFENEGQFTLIGIVLGLAIYNNCILDVHFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLMEY 650

Human   669 EGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAF 733
            |||||:|||||||||||||||||:||||||:|||||:||||||:||.||::|:||||||||||||
Zfish   651 EGNVEEDMMITFQISQTDLFGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAF 715

Human   734 RRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFT 798
            |||||||||||||||||||||||||||||||||||||||:|||||||.:||.:||:|||.||||.
Zfish   716 RRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFE 780

Human   799 DEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 863
            .|:||||||||||||||||||||||||||||||||::||||||||||||||||||:.||||||||
Zfish   781 QEKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDSDRLPTSHTCFNVLLLPEYSTVEKLKERLL 845

Human   864 KAITYAKGFGML 875
            ||||||||||||
Zfish   846 KAITYAKGFGML 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862	47/53 (89%)
UBE3A	NP_000453.2	HECTc	523..873	CDD:238033	321/349 (92%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166	47/53 (89%)
		HECTc	505..855	CDD:238033	321/349 (92%)
		HECTc	532..854	CDD:214523	293/321 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194323562
Domainoid	1	1.000	820	1.000	Domainoid score	I756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7988
Inparanoid	1	1.050	1491	1.000	Inparanoid score	I958
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47992
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	1	1.000	-	-		FOG0008299
OrthoInspector	1	1.000	-	-		oto49555
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	1	1.100	-	-	LDO	PTHR45622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5642
SonicParanoid	1	1.000	-	-		X6282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440