DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UBE3A and Ube3a

DIOPT Version :9

Sequence 1:	NP_000453.2	Gene:	UBE3A / 7337	HGNCID:	12496	Length:	875	Species:	Homo sapiens
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	397/976 - (40%)
Similarity:	560/976 - (57%)	Gaps:	161/976 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    24 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC----- 83
            |||:|.:.||:||:|||..||||..|:|..|||......|..|..|.:||:|:..:|:||
  Fly    35 MKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTS 99

Human    84 --------------DPHPSKKGASSAYLENSK--------------------GAPNNSCSEIKMN 114
                          |...|..|:|::.:.::.                    .:|..:.|..:::
  Fly   100 EANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLD 164

Human   115 KKGARIDFKD----------VTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRK 169
            ..||.....|          |..|....:..:.|.||..:.|..:...||.||||.:.|.:||.:
  Fly   165 IAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIR 229

Human   170 VKQH-----------------TKEELKSLQA---KDEDKDE--DEKEKAACSAAAMEEDSEASSS 212
            ..:.                 .||:|::|:.   ||||..:  ||:.::|.:|.|..|..|:.:
  Fly   230 SAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEA- 293

Human   213 RIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN---EKIETAFLNALVYLSPNVECDLTYH 274
               :..:.|:::......|..||:..:||| .|||..   ..|.....::::.||..|
  Fly   294 ---EPEEEDDDVCSSQSSDTLVDLPGLRRV-QRLLFGCQIRAITEKLTSSVIQLSDWV------- 347

Human   275 NVYSRD--PNYLNLFIIVME-----NRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYN 332
             :|.|.  ...::..:|..:     |.::...:||:..||..|:|.|.:|:.||.:|.|:|:.:.
  Fly   348 -IYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHC 411

Human   333 ADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVD-------- 389
            :||:..::...||.||.:|:.:|.:.|    ::::|::.:|.||:|:|||::..|::
  Fly   412 SDQLHSLIAACQQQITLQVLLDEESMR----ENESIISVTKVLKIVFYANILASELERPSCRVPL 472

Human   390 TNHNE----------EDD--------EEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKT 436
            .:..|          |||        |..:|:.:|                   |..|.||.|..
  Fly   473 EDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAE-------------------DQFEKELQVSA 518

Human   437 LDCRKPLIPFEEFINEPLNEVLEMDKDYTFFK---VETE------NKFSFMTCPFILNAVTKNLG 492
            :||||||||.|||.||.|:|.::|..||..:|   :|:|      |.||||...|||...||...
  Fly   519 IDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDA 583

Human   493 LYYDNRIRMYSERRITVLYSLVQ-----GQQLNPY--LRLKVRRDHIIDDALVRLEMIAMENPAD 550
            ||||:|:||||| |.:.|:|::.     ||:.||.  |:|.||||.:|:|||:.|||:||.||.|
  Fly   584 LYYDSRMRMYSE-RYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKD 647

Human   551 LKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLI 615
            |||||.|||.||||:||||||||||||:|||||||..|||...|.|...|||.:.||...|||||
  Fly   648 LKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLI 712

Human   616 GIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEG-NVEDDMMIT 679
            ||::|||||||..|.|:|||||||||:|..|||.||.|..|.||:|||.:|:|:| ::|:....|
  Fly   713 GIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQT 777

Human   680 FQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNES 744
            |:||.:|:||:.:.::|..||..:.:...|::.|||||||::||.::|:||.|||:||.|||:||
  Fly   778 FKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDES 842

Human   745 PLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFT 809
            |||.||||||||:|:||||..||..||.:|.|:||||..|..|::||.|||:...|.|...|:||
  Fly   843 PLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFT 907

Human   810 TGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
            ||:.|.|||||..|:::|.::|||::|||||||||||||||||||:|||:|||:|||.|:|||||
  Fly   908 TGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972

Human   875 L 875
            |
  Fly   973 L 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862	23/53 (43%)
UBE3A	NP_000453.2	HECTc	523..873	CDD:238033	216/350 (62%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	23/53 (43%)
		HECTc	620..971	CDD:238033	216/350 (62%)
		HECTc	647..970	CDD:214523	198/322 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140823
Domainoid	1	1.000	371	1.000	Domainoid score	I904
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7988
Inparanoid	1	1.050	650	1.000	Inparanoid score	I793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47992
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	1	1.000	-	-		FOG0008299
OrthoInspector	1	1.000	-	-		oto91264
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	1	1.100	-	-	LDO	PTHR45622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5642
SonicParanoid	1	1.000	-	-		X6282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940