Protein Alignment UBE3A and Herc4

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 770
• Identity: 226/770 - (29%)
• Similarity: 378/770 - (49%)
• Gaps: 130/770 - (16%)

Human   152 VIGRVFSSAEALV------------QSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAME 204
            ||.::||..:..:            :.||  ..:.|.::.:|.|      |..|:.|.|......
  Fly   377 VIRQIFSGGDQSIVTTTLFVDKVPPEDFR--NYNPKSQILTLTA------EVTKQCAQCKQGLQS 433

Human   205 EDSEASSSRIGDSSQGDNNLQKLGPDD---------VSVDIDAIRRVY--TRLLSNEKIETAFLN 258
            :....||..:...||...|...|...|         ..:|:.|.:..:  .|.:.||.|.....:
  Fly   434 DMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWD 498

Human   259 ALVYLSPNVECDLTYHNVYS-RDPNYLNLFIIV-MENRNLHSPEYLEMALPLFCKAMSKLPLAAQ 321
                   |:..:|....|.| .|...:.|:::: :.:..::|..|..:.:| |..|:.||   |:
  Fly   499 -------NITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVP-FANAIFKL---AE 552

Human   322 G--KLIRLW-SKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 383
            .  |::..| ::..|:....:::.|..::.: :||.:.          .:.|||
  Fly   553 NPRKVLNKWLAQTPAEYFEHLVQNFLHVVIH-IISFKM----------GLAAAS----------- 595

Human   384 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGV-----KTLDC---- 439
                            |..|..    |:||             |..|||.:     ||| |
  Fly   596 ----------------PSAERR----QQLL-------------PYNTELEIILKLMKTL-CQINN 626

Human   440 -RKPLIPFEEFINEPLNEVLEMDKDYT-FFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMY 502
             |...:.::.|....|::..::.::|. :...:|...|:.....||.:...|...|..|..::|:
  Fly   627 ERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMH 691

Human   503 S--ERRITVLYSLVQ-GQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQG 564
            |  ....|:.:|... |..::.::.|.|.|::::.|:|..|:..:.   :||||.|.::|.||:.
  Fly   692 SAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQ---SDLKKPLKIKFHGEEA 753

Human   565 VDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCIL 629
            .|.|||.||||.|:::::.:|..|||...|.::|.||...:||||..:.|||::.||||||..|:
  Fly   754 EDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTII 818

Human   630 DVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMM----ITFQISQTDLFGN 690
            ::.||:.:::||:||.....||....|....|::.||:|:|   ||..    :||:||: |:||.
  Fly   819 NLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQG---DDFKEVFDLTFEISR-DVFGE 879

Human   691 PMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEI 755
            .....||.||::|.:|.|||:|||:||.|::.|||||..:.||.:||..|.:...: ::|:|||:
  Fly   880 AETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVI-HIFQPEEL 943

Human   756 ELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGL 820
            ..::.|:.:.|:|||::..||..|||.....|:.|||::|..::.:|:.||.|.||:||.|:.|:
  Fly   944 MAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGM 1008

Human   821 GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 875
            ..||:.|... ||...||.:|||||:|.||.|.:||:||.:||:||...:||.::
  Fly  1009 KALKLTIQPT-PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	147/353 (42%)
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065
		RCC1	327..390	CDD:395335	4/12 (33%)
		HECTc	715..1060	CDD:238033	147/353 (42%)