Protein Alignment UBE3A and Smurf

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 111/582 - (19%)
• Similarity: 190/582 - (32%)
• Gaps: 158/582 - (27%)

Human    36 RSQILGLPQ---AVPWREIQ----QWLP--FSPP-----VPIADYISQKRPQFLGSPFFCLRDP- 85
            :||.:..|.   |.|:|.::    ...|  |..|     ||:.   |..:|...|:....|||.
  Fly   392 QSQTVATPNTVLATPFRSVRGPDGSATPGGFLTPASGAMVPVG---SGTQPHAPGATPNFLRDKL 453

Human    86 ---HRPGTGKCTKQVAFSDV--SLDFSQEEWACLGPAQRALYKDVMLENYSHLLSVAG-----LH 140
               ...|........|:...  .|..|.:|.....||.|..|:.|:.:|.:...:..|     ..
  Fly   454 NINTEDGMSVAETPAAYKSYQKQLKSSLKEGLASLPAPRNDYEIVVPDNETDEAADDGSMDVEQM 518

Human   141 IP-------KPQVISLLEQGKEPWMVGKELTRGLCSALESMCESKLLSLKKEVYELESCQREFMR 198
            :|       |.:...|.::.||..:..:.:.|.|...||  ..:.:|....|::.|...|:. ..
  Fly   519 VPDQADVDEKRKRNKLAQEAKELSLRSQVIQRDLPRPLE--INTTVLRPSNEMHGLTDLQKA-EE 580

Human   199 LTKQG----LDYPGFRDVLECGSQLQNGHGSQEPLAREYMPTFVQQTFLTLHQIINDEKPY---- 255
            |.||.    |:|...|:.::                 :..|..|::..|:.:|...::.||
  Fly   581 LVKQEMVKMLNYDALRNPIQ-----------------QSQPASVKRPMLSQYQAYLEQHPYETID 628

Human   256 --ECKKCRKVFTQNSQFIQHQRIH--IGEKSY-----ECKECGKFFSCGSHVTR----------- 300
              |..:.||:.......::|...|  :..:||     ||.....:....:..||
  Fly   629 EVELDEARKMLAAEMGVVKHGMAHGDLSLESYTQVWQECLSQVLYLPSQNRYTRANLASKKDRIE 693

Human   301 ----HLKIHTGEKPFECKDCGKAFSCSSYLSQHQRIHTGKKPYECKDCGKAFSYCSNLIDH---- 357
                .|:|:......|.|.|||       :.:..:|.|.......:...|.|...:..|:.
  Fly   694 SAEKRLEINRKHMAKEAKRCGK-------IEKKLKILTAGYQARAQALVKQFQDTNEQIEQNSLA 751

Human   358 ------------------------------QRIHTGEKPYACKVCGKAFTKSSQLFQHVRVHTGE 392
                                          :|..|.:..||  ...:...:.:.|.:..||: |.
  Fly   752 LSTFKFLAAQEDLAIPKRLESLTEDVMRQTEREKTLQNRYA--QLTEELEELNHLLEEARVN-GV 813

Human   393 KPYECKECGKAFTQSSKLV----QHQRIHTGEKPY--------ECKECGKAFSSGSALTNHQRIH 445
            :.:|  |.||   :...||    :|:.:...|:|.        |.....:..|..:|..:....:
  Fly   814 QEHE--EGGK---EREPLVNGRLEHREVEEKEEPVVDNPTNGPEDSNVQEESSDSNAAEDEPPEN 873

Human   446 TGEKPYECKDCGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRV--HSDEK 505
            .||        |.|..|..|....:....|:...|..|......:|.:..|.:.:  |.||:
  Fly   874 EGE--------GNAVAQERQSESPEESVPGQDSCESEENTSEGQENQEQQQDEPMEQHDDEE 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173	14/60 (23%)
		HECTc	523..873	CDD:238033
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028
		PRP40	155..>283	CDD:227435
		WW	169..198	CDD:459800
		WW	514..546	CDD:197736	5/31 (16%)
		WW	562..594	CDD:197736	9/32 (28%)
		HECTc	702..1058	CDD:238033	44/249 (18%)