Protein Alignment UBE3A and Su(dx)

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 155/516 - (30%)
• Similarity: 254/516 - (49%)
• Gaps: 77/516 - (14%)

Human   395 EDDEE---PIPESSELTLQE-----LLGEERRNK--KGPRVDPLETELGVKTLDCRKPLIPFEEF 449
            :|||:   |:|:..|..:|.     .:..:.|..  :.||....|..|
  Fly   470 QDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSL----------------- 517

Human   450 INE-PLNEVLEMDKDYT-----FFKVETENKFSFM-TCPFILNAVTKNLGLY-----YDNRIRMY 502
            ||| ||....|:  .||     ||......:.:|. ..|   .|.....|:|     |:...|.
  Fly   518 INEGPLPPGWEI--RYTAAGERFFVDHNTRRTTFEDPRP---GAPKGAKGVYGVPRAYERSFRW- 576

Human   503 SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA-DLKKQLYVEFEGEQGVD 566
               :::....|.|...|..::::.|.|..:.:|:..::    |..|| :|:::||:.|.||:|:|
  Fly   577 ---KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MRLPAYELRRRLYIIFRGEEGLD 634

Human   567 EGGVSKEFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNC 627
            .||||:|:|.|:..|:.||...:|.| :::......||:|:.....   |..||..:.:|:|:..
  Fly   635 YGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGR 699

Human   628 ILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL---KDLLEYEGNVED-DMMITFQISQTDLF 688
            .:...|.|..|::::.||.|.:|:....|..|.||   ||     .|::: .:.:.|.: ..::.
  Fly   700 FIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKD-----NNIDECGLELWFSV-DFEVL 758

Human   689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPE 753
            |..:.::|||||:|..:|.||::|::.|.:::.:.:.:|:|.|.|..||:.|.....||| |...
  Fly   759 GQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY-FDER 822

Human   754 EIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG 818
            |:||::||.:::|.:..:..|.| ..|.|:|..:..||:.|....:|::...|||.|||.|.|||
  Fly   823 ELELILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVG 886

Human   819 GLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
            |..:|       :..|.|.|.:| .||.||||||.|.||.|.|.::|.|:|..||...:||
  Fly   887 GFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	123/366 (34%)
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		HUL4	<395..946	CDD:227354	153/514 (30%)