Protein Alignment UBE3A and Hecw

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 395
• Identity: 128/395 - (32%)
• Similarity: 203/395 - (51%)
• Gaps: 29/395 - (7%)

Human   495 YDNRIRMYSERRITVLYSLVQGQQLNPY-LRLKVRRDHIIDDALVRLEMIAMENPADLKK-QLYV 557
            ::.::|.:..:    |.|...||  .|: |:|.:||.|:::||..|   |...|..||:: :|.|
  Fly  1045 FEAKLRSFYRK----LESKGYGQ--GPHKLKLHIRRSHLLEDAFRR---IMSANKKDLQRGRLAV 1100

Human   558 EFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNP-SSF--ETEGQFTLIGIV 618
            .::.|:|:|.||.|:|||.|:..|:|||..|:|.|. ..|.....:| |:|  .....|...|.|
  Fly  1101 LWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRV 1165

Human   619 LGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 683
            ||||:.:..:||..|....|:.|:.......||.......:|||:.:.:.:.....|:.:||.::
  Fly  1166 LGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVT 1230

Human   684 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
            : :|.|:.:..:||..|..|.|..:|:||::.....:.|.:.|::|.::..|||:.|. :|.|..
  Fly  1231 E-ELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVI-DSRLVS 1293

Human   749 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTD 813
            :|...|:||:|.|:..:|.......|||..||..:..:|..||:::..|::||:...|||.|||.
  Fly  1294 VFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTS 1358

Human   814 RAPVGGLGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 869
            ..|..|...|:   ...||         ....||.:|||||.|.||.|.:.|.|.|:||.|:...
  Fly  1359 SIPYEGFSALR---GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEET 1420

Human   870 KGFGM 874
            ..||:
  Fly  1421 NTFGI 1425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	120/363 (33%)
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021
		WW	638..667	CDD:459800
		HECW1_helix	738..794	CDD:465766
		HECTc	1068..1424	CDD:238033	120/363 (33%)