DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UBE3A and mug30

DIOPT Version :9

Sequence 1:	NP_000453.2	Gene:	UBE3A / 7337	HGNCID:	12496	Length:	875	Species:	Homo sapiens
Sequence 2:	NP_596534.1	Gene:	mug30 / 2541379	PomBaseID:	SPBP8B7.27	Length:	807	Species:	Schizosaccharomyces pombe

Alignment Length:	928	Identity:	237/928 - (25%)
Similarity:	387/928 - (41%)	Gaps:	212/928 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    11 SGEPQSDDIEASRMKRAAAKHLIERY----------YHQL--TEGCGN-EACTNEFCASCPTFLR 62
            |...:.|:...|::.|...:.:.:|.          :|:.  .:..|| |......|..|.:.||
pombe    27 SSRSELDNNTNSKISRRLRELVCQRMGENPLRLRQSFHETISNDSYGNSEKLVIRPCICCNSVLR 91

Human    63 MDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTY 127
            ....|...:......:|    |.:....|                 |:||.........|..|.:
pombe    92 YPAQAMCFRCSLCMTVN----DVYFCLSG-----------------SQIKTKASTDGSQFISVEH 135

Human   128 LTE--EKVYEILELCREREDY--------SPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQ 182
            ..|  .:....|:|.::|...        .||..:|..||.|...|.:.|
pombe   136 FVETIHQTRSALQLAKQRTGNVQAIVAAGLPLRELISLVFGSPPILNKLF--------------- 185

Human   183 AKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLL 247
                      ..|..||              |..|......:.:|..|..::||         |:
pombe   186 ----------SVKNGCS--------------IQSSGLNYKLIYQLYHDITNLDI---------LI 217

Human   248 SNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSP-----EYLEMALP 307
            :||.:..            :|..|....:|..||......:|::||..|:|.     ......|.
pombe   218 TNELLRA------------IESLLRRPMLYCHDPADYQYLLILLENPLLNSKSKNIVNKSSSILK 270

Human   308 LFCKAMSKLPLAAQGKLIRLWSK--YNADQ-IRRMMETFQQLITYKVISNEFNSRN----LVNDD 365
            .....:|.|........|..:.|  ||..: .||.::...:.|..:::  |..|||    ..|:|
pombe   271 RILGVLSNLNEKTHHFFISCFKKQPYNNPKFFRRKVDLINKFIGQRLM--ETYSRNKRKHYYNND 333

Human   366 DAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLET 430
            ..|.:|:..:.::|.||                      |::.|
pombe   334 WQIKSAAITMALLYSAN----------------------SQMRL--------------------- 355

Human   431 ELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYY 495
                  :|.........:|||        :..|:..:: :..|.|.|...||:|:...|...|..
pombe   356 ------IDRSSFYCIMADFIN--------LYHDFELWE-QKINCFCFCQYPFLLSMGAKISILQL 405

Human   496 DNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFE 560
            |.|.:|..:.|.....|::....:.|||.::||||.:::|:|.::.    :...|.:|.|.|||.
pombe   406 DARRKMEIKAREAFFSSILSKMNVEPYLMIRVRRDRLLEDSLRQIN----DRNKDFRKALKVEFL 466

Human   561 GEQGVDEGGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETE-GQFTLIGIVLGLAI 623
            ||:|:|.||:.:|:..|:..::|:|:.|:| ..:||:...|||.|....| ..:.:.||::|:||
pombe   467 GEEGIDAGGLKREWLLLLTRKVFSPEFGLFVNCEESSNYLWFNYSHRSKEIDYYHMSGILMGIAI 531

Human   624 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
            :|:..|||..|...|:||:....:|.||.|..|.||:.||:||.:||:|::...:.|.|:...:.
pombe   532 HNSINLDVQMPRAFYKKLLQLPLSFNDLDDFQPSLYRGLKELLLFEGDVKNTYGLNFTINLKAVE 596

Human   689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPE 753
            |...: :|||.|.::.:.||||||:|..|.||:||.:|:|||.||..||..|...:.:. ||:..
pombe   597 GFRTV-ELKEGGSELSVDNENRKEYVLRYVDYLLNTTVKKQFSAFFDGFMKVCGGNAIS-LFQDN 659

Human   754 EIELLICGSRN-LDFQALEETTEYDGGYTRDSV--------------------------LIREFW 791
            ||..||.||.. :|::.|:....|| .|.::::                          :|..||
pombe   660 EISKLIRGSEEVIDWELLKNVCVYD-FYDQNAISNSISESEPSMTASKYLCHSFVSKRKIILWFW 723

Human   792 EIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKE 856
            :::..::.:.::|||.|.||:||.|..|....::.|:..|||:::||.||||||.|.:.||||:|
pombe   724 DLISHYSLKMQKLFLIFVTGSDRIPATGAHNFQLRISVLGPDSDQLPISHTCFNHLCIWEYSSRE 788

Human   857 KLKERLLKAITYAKGFGM 874
            |||::|..|:....||.:
pombe   789 KLKKKLDTALLETNGFNI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862	11/66 (17%)
UBE3A	NP_000453.2	HECTc	523..873	CDD:238033	137/378 (36%)
mug30	NP_596534.1	HUL4	1..807	CDD:227354	237/928 (26%)
		ZnF_UBP	100..152	CDD:197632	11/72 (15%)
		HECTc	433..804	CDD:238033	136/377 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	202	1.000	Domainoid score	I746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53795
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810