Protein Alignment UBE3A and eel-1

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_001294472.1
• Gene: eel-1 / 177084
• WormBaseID: WBGene00022069
• Length: 4185
• Species: Caenorhabditis elegans
• Alignment Length: 774
• Identity: 196/774 - (25%)
• Similarity: 317/774 - (40%)
• Gaps: 189/774 - (24%)

Human   140 CREREDYSPLIRVI----GRVFSSAEALVQSFRKVKQHTK--EELKSLQAKDEDKDEDEKEKAAC 198
            |:|.:  .|.:.|:    |..::...|| |:..||:.|.|  .:.|:.:|||.:|...|||..:.
 Worm  3559 CKELQ--LPAVTVLTDKGGAQYALLSAL-QTLVKVRNHMKAIRKDKAKRAKDAEKKLKEKETPST 3620

Human   199 SA-AAMEEDSEASSSRIGDSSQGDNN--------LQKLGPDDVSVDIDAIRRVYTRLLSNEKIET 254
            || ||....:.|.::.....:..:||        |:::..::        .|:..||.|.|.:..
 Worm  3621 SAPAAPAAPATAPTAPAAPDAPVENNEVPEPAAELEEVNDEE--------PRISERLSSLESLWN 3677

Human   255 AFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLA 319
            :....|:.|..            :.||:.:                   :||....:|...:..:
 Worm  3678 SLSECLLRLGK------------ASDPHAV-------------------LALQPAAEAFFLVHAS 3711

Human   320 AQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVV 384
            .|.||    ...:|:..|:..:                            |||...     |..|
 Worm  3712 QQNKL----KAKDAEAKRKESQ----------------------------AASSSA-----AAAV 3739

Human   385 GGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEF 449
            ...|..:...||                            :||          |..| ||.|.|.
 Worm  3740 ASSVSHDGLRED----------------------------LDP----------DTAK-LIEFAEK 3765

Human   450 INEPLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLYSL 513
            ..:.||:.|..:...    :.....|:.:| .|.:|:...|          |.|..:.:|.|..
 Worm  3766 HRQVLNQALRQNNAV----LSAGGPFAILTQFPKLLDFDVK----------RKYFRKELTKLEP- 3815

Human   514 VQGQQLNPYLR----LKVRRDHIIDDA---LVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVS 571
             ...::..|.|    ::|.|:.:..|:   |.||      .|::.|.:.|:.|:||:|.|.||:.
 Worm  3816 -SNSRMPRYRRNDVSVQVSRNRVFSDSFRELFRL------RPSEWKNRFYIIFQGEEGQDAGGLL 3873

Human   572 KEFFQLVVEEIFNPDIGMF--------TYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCI 628
            :|:|.::..|||||:..:|        || ...|..:.||...:   .|..:|.::..:::.:..
 Worm  3874 REWFSVITREIFNPNYALFITAPGDMVTY-MINKASYINPEHLD---YFKFVGRLIAKSVFEHKY 3934

Human   629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS-QTDLFGNPM 692
            ||.:|....|:.::.....::||....|..::||..||:   |..||:.:....| :.:.||...
 Worm  3935 LDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQ---NPIDDLALDLTFSTEVEEFGVRS 3996

Human   693 MYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
            :.|||.||.||.:.:.|:.|:|.|.....:..|:.||..||..||:.:..:. |..:|..:|:||
 Worm  3997 VRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKD-LISMFNEQELEL 4060

Human   758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGK 822
            ||.|...:|...:...|:|. |:.:.|..|:.||..:.||..|.|..||||.|||.:.|:.|...
 Worm  4061 LISGLPTVDIDDMAANTDYK-GFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFAS 4124

Human   823 L-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYAKGFG 873
            |       |..|..:....:|||.:|||||.|.||:|.|.|||::.||.|| ...:|||
 Worm  4125 LEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIRECTEGFG 4183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	120/373 (32%)
eel-1	NP_001294472.1	DUF908	95..375	CDD:428721
		DUF913	576..935	CDD:461803
		UBA_VP13D	1442..1476	CDD:270491
		WWE	1787..1846	CDD:460715
		PRK12323	<2950..3132	CDD:481241
		UBM	2980..3009	CDD:464159
		UBM	3050..3080	CDD:464159
		HECTc	3830..4183	CDD:238033	119/367 (32%)