Protein Alignment UBE3A and oxi-1

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_499392.1
• Gene: oxi-1 / 176515
• WormBaseID: WBGene00003898
• Length: 1066
• Species: Caenorhabditis elegans
• Alignment Length: 901
• Identity: 199/901 - (22%)
• Similarity: 353/901 - (39%)
• Gaps: 251/901 - (27%)

Human    71 KALE--LYK------INAKLCDPHPSKKGASSAYL---------------ENSKGAPNNSCSEIK 112
            |.||  ||:      ::...|.....|.|.:...|               :.::||..|...::|
 Worm   315 KTLESKLYEWTWAVGVSLSRCTELTVKHGGTKTSLHYWHPVFGHYLLPIDKRTEGALRNVLFQLK 379

Human   113 M--NKKGARIDFKDVTYLTEEKVYEILELCRERED----YSPLIRVIGRVFSSAEALVQSFRK-- 169
            |  :.:..|..|.::...|:...:.:.:..:..:|    :|.|.|.:|....||.:..:|..:
 Worm   380 MLWSSRVVRCLFGNIMENTKTASFSVTDGQKNSKDISAAFSKLWRKLGGSTDSASSSSKSESEPP 444

Human   170 ----------------VKQHTKEELKSLQAKDED---------KDEDEKEKAACSAAAMEEDSEA 209
                            ...|.|.|:.|...:|:.         ::..||             :..
 Worm   445 PTLIAIVCQVYMTALNTMVHMKGEIISGLCRDDQLLKQLWTYLREWGEK-------------AGG 496

Human   210 SSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYH 274
            :|..|.:||    |.::.||  ||..:.:::|       .....||.|...|..:..:...|...
 Worm   497 TSGSIFNSS----NAEQWGP--VSASLQSLKR-------PSSPHTATLRLFVDCAAAIISILDEE 548

Human   275 NVYSRDPNYLNLFIIVMENRNLHS-PEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRR 338
            .::.::..:        .|:.|.| .:|:.    :||             ...:||....:....
 Worm   549 EIFEKETPF--------SNKELESICKYVN----IFC-------------FRSIWSGAVDETSAN 588

Human   339 MMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPE 403
            ....|..:.:...:..|.:||.....:|:        |....:.|                   :
 Worm   589 TTGLFHSMHSLLTVLYERDSRRSFAANDS--------KFWLISEV-------------------K 626

Human   404 SSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRK--PLIPFEEFINEPLNEVLEMDKDYTF 466
            .|.||::    .|:::.||             .|..||  .|:|.:             |:...|
 Worm   627 PSSLTIE----YEKKSGKG-------------VLMMRKMAHLVPIK-------------DRMLLF 661

Human   467 FKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLR--LKVRR 529
            .:...::|          |.|..:|.                           :|.::  :.|:|
 Worm   662 RRQVQDDK----------NRVATSLN---------------------------DPQMQTWITVQR 689

Human   530 DHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVS-----KEFFQLVVEEIFNPDIGM 589
            :.||:|....|..:.:  || ||..:.|:|..|||:||.|:.     |||.:|.::::|:|.:.:
 Worm   690 NRIIEDGFNHLSKLTI--PA-LKSTIRVKFVNEQGLDEAGIDQDGVFKEFLELTLKKVFDPQLNL 751

Human   590 FTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMG--KKGTFR 649
            |: ..||.:.:.:|:|...:..   ||.:|.:||.|:|...::||....|:...::|  :...|.
 Worm   752 FS-TTSTGVLYPSPTSSLHDDHLALFTFVGRMLGKAVYEGIVVDVQLAPVLLAAVLGSHRLCAFD 815

Human   650 DLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFV 714
            :|....|.||:||..:..|||.:. |:.:||.:.: |..|.....||..:|..|.:||||:.::|
 Worm   816 ELSQLDPELYRSLTFVKRYEGEMA-DLSLTFSVDE-DFMGKISTVDLVPSGRTISVTNENKIDYV 878

Human   715 NLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICG-SRNLDFQALEETTEYDG 778
            :..:.:.:.:..::|.|||..|...:...:.|. ||.|.:::.||.| :.::|...|:...:|.|
 Worm   879 HRMAHHRVFRRTQEQCKAFVTGMQSILQPTWLS-LFAPNDLQCLISGVNSDIDLADLKRNVQYFG 942

Human   779 GYTRDSVLIREFWEIV-HSFTDEQKRLFLQFTTGTDRAPVGGLGKLK------------------ 824
            |:..:..||:..|:|: :.||.|:::|||:|.|...|.||.|...|:
 Worm   943 GFHGNHRLIKWLWDILENKFTSEERKLFLKFVTSCSRPPVLGFSYLEPPFSIRCVEVSDDQDQGD 1007

Human   825 --------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
                    .:..:.|....||||:.||||:|.||.|:.|..|.|:|..||....||
 Worm  1008 TLGSVVRGFLALRKGTAATRLPTASTCFNLLKLPNYNKKSLLLEKLRYAIHAGTGF 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173	5/19 (26%)
		HECTc	523..873	CDD:238033	119/390 (31%)
oxi-1	NP_499392.1	HECTc	684..1064	CDD:238033	119/387 (31%)