Protein Alignment UBE3A and hecw-1

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_001317872.1
• Gene: hecw-1 / 175438
• WormBaseID: WBGene00009738
• Length: 1247
• Species: Caenorhabditis elegans
• Alignment Length: 595
• Identity: 159/595 - (26%)
• Similarity: 267/595 - (44%)
• Gaps: 88/595 - (14%)

Human   339 MMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEE-------- 395
            :::.||:        :||.:. |..:.||:...::|..:.:..:.:..::|.....|
 Worm   681 LIQFFQR--------DEFKTA-LYENQDAMQIYNECSVVRHAIHRIQKDLDPPSKFENQPLFVRF 736

Human   396 -----DDEEPIPESSE-LTL-QELLGEERRNKK----GPRVDPLETE------------------ 431
                 |..:|:|...| :|: ...:.....||:    .||:...||:
 Worm   737 VNLFADITQPLPSGWECITMNNRTVFLNHANKETSFYDPRIRRFETKTSRRGRSVPSRSSTAHKG 801

Human   432 -----LGVKTLDCRKPLIPFEEF--INEPLNEVLEMDKDYTFFKVET-ENKFSFMTCPFILNAVT 488
                 |..|..|.||  |..:.|  |.|.:::.|.:.:.:....|.: .|.........:|::.|
 Worm   802 KIDHALISKCEDLRK--IAQDNFPQIAERISKKLMLIERFGGLAVASLANDLDITLALSMLDSNT 864

Human   489 KNLGLYYDNRIRMYSERRITVLYSLVQGQQLN---PYLRLKVRRDHIIDDALVRLEMIAMENPAD 550
            :.|....|| |:|:        |..::.::|.   ..|..||.||.::|||   ..:|...:|..
 Worm   865 EKLAGEGDN-IKMF--------YEDMKKEKLGKGPSRLCWKVSRDRLLDDA---FRIILNVDPFV 917

Human   551 LKK-QLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ--- 611
            ||| :|::.||||..:|.||:|:|||.|:..|:|:|..|.|.|:.:.......|...|||.:
 Worm   918 LKKSRLHIRFEGELALDYGGLSREFFILLSRELFHPKNGYFEYEGNDYHLQLRPRGCETEKEKKW 982

Human   612 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDM 676
            ..|.|.||.||:.:.|.:||.|..|.|:.|..:..|..|..:|....|:|:..|||   |...|:
 Worm   983 LILCGRVLALAVIHRCYIDVFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLE---NDVVDL 1044

Human   677 MITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVT 741
            .::|..|.. :.|.....:|...|:...:|..|:.||::|.......:.|||..:.....|:.:.
 Worm  1045 EMSFVYSSM-VNGKLAEQELVPGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQIL 1108

Human   742 NESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 806
            |::.|..| ...:::.::.||..||.......|.|.|||:...:::..|||::.:.|::::...|
 Worm  1109 NDNLLNSL-ESSDLKRILSGSLELDLNDWRTNTIYKGGYSDCHIVVEWFWEVIETMTNQERFDLL 1172

Human   807 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLK 864
            .|.||:...|..|...|       |..|.|.| |....|.:|||||.|.||.|::|::||.:|.:
 Worm  1173 LFVTGSSSVPFEGFSALRGNEEISKFCIEKWG-DATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQ 1236

Human   865 AITYAKGFGM 874
            ||.....:.:
 Worm  1237 AIVNGMSYSI 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	117/360 (33%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:429626
		WW	603..634	CDD:197736
		HECW1_helix	679..741	CDD:465766	10/68 (15%)
		WW	746..777	CDD:197736	7/30 (23%)
		HECTc	918..1244	CDD:214523	107/331 (32%)