Protein Alignment UBE3A and etc-1

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_495842.1
• Gene: etc-1 / 174388
• WormBaseID: WBGene00008429
• Length: 1001
• Species: Caenorhabditis elegans
• Alignment Length: 888
• Identity: 206/888 - (23%)
• Similarity: 362/888 - (40%)
• Gaps: 207/888 - (23%)

Human    58 PTFLRMDNNAAAIKALEL---YKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGAR 119
            ||.....|...|:|::::   :|:..::.:  .:.....|.::.......|....::|..
 Worm   245 PTSPNFTNLFEAMKSVDILNNWKVRPEIAE--TASLRLQSIFVSQIVHVSNTQSEDVKQY----- 302

Human   120 IDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAK 184
              |..:....|.. .:|:.....:||.|.    .||:.:|..      ..:||:.:|.|.|
 Worm   303 --FNSLAVFLEHH-SKIMRSLNVKEDLSE----FGRLRTSVN------NHLKQYCEEMLIS---- 350

Human   185 DEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVD-IDAIRRVYTRLLS 248
                  :|..:|||..|                     ||     ..|.|: |.::|:.:::.|.
 Worm   351 ------NEFRRAACIYA---------------------NL-----PGVQVETIISLRKYFSQFLD 383

Human   249 NEKIETAFLNAL----VYLSPNVECDLTYHNVYSRDP--NYLNLFIIVMENRNL----------- 296
            .......|:.||    ..|.||.|.|    .:.::.|  |.|.||...:..|..
 Worm   384 LLAASNTFVEALYAFIARLCPNGEFD----PIDAKSPKVNALELFCNCLNKRVSSVADSDFVPTD 444

Human   297 ------HSPEYL-EMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRM--METFQQLITYKVI 352
                  |:.|:| ::::.|.   ....|..|:|.|      |:.:...:|  .||..:.:|..|.
 Worm   445 IFVDFDHTVEFLRDVSIKLI---HLMFPTMARGDL------YSGNLKEKMYKAETDWKDVTESVF 500

Human   353 SNEFNSRNLVNDDDAIVAA--SKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGE 415
            |              |:.|  .|.:::.|:..    |..|||..|             :...:||
 Worm   501 S--------------ILGAIYQKDIRLKYFPE----EFWTNHGRE-------------VLSGIGE 534

Human   416 ERR--NKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFM 478
            .||  .::.|. ..|:.|   :|:|        .||: |.|..:.|||.|     .|.:::....
 Worm   535 HRRMPRRRMPN-GRLQIE---RTMD--------TEFV-ERLAAIYEMDSD-----SENDDEDEDN 581

Human   479 TCPFILN---AVTKNLGLY--YDNRIRMYS-------ERRITVLYSL-VQGQQLNPYLRLKVRRD 530
            ..|.:|.   .|.|::...  :.:|:::::       |:..|..:.: ..|..:.      ||||
 Worm   582 NLPAVLRRAICVMKHIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPSVT------VRRD 640

Human   531 HIIDDALVRLEMIAM----ENPADLKKQLYVEF-----EGEQGVDEGGVSKEFFQLVVEEIFNPD 586
            .:..||   .|..|.    :...|||..:.|:.     ..|.|:|.||:.:||...:::..||.:
 Worm   641 QVYMDA---FETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVE 702

Human   587 IGMFTYDESTKLFWFNPSS-----FETEGQFTLIGIVLGLAIYNNCILDVHFP----MVVYRKLM 642
            .|.||:.|| ||.:.||::     .:....|..||.::|..||...:.:|.|.    ..::....
 Worm   703 RGFFTFTES-KLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDK 766

Human   643 GKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITN 707
            .|....:.:....|::::.||.|.:......|::.:.|.:..:|: |.....:||.||.|..:|.
 Worm   767 NKDVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDM-GLVRNVNLKPNGSKFRVTV 830

Human   708 ENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEE 772
            ||..|:|.||.:|.|.:.:.....|.|:|...:.:...:: :|.|.|::::|.|...: |.|.|.
 Worm   831 ENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMR-MFAPHELQIMIAGYEEV-FTAKEL 893

Human   773 ----TTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLK----MIIAK 829
                ...:..| |:|......||:::...:::.|:..|:|.||..||||.|...::    :::..
 Worm   894 RKFCELRFAAG-TQDINYEEMFWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLVIP 957

Human   830 NGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
            :..|  .||||.||.|:|.:|:||::.||:|:|..||....||
 Worm   958 SSDD--ELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGF 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173	6/27 (22%)
		HECTc	523..873	CDD:238033	107/376 (28%)
etc-1	NP_495842.1	IQCG-IQCD	19..>47	CDD:483958
		HECTc	661..998	CDD:214523	97/343 (28%)