Protein Alignment UBE3A and herc-1

DIOPT Version :9

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_490834.1
• Gene: herc-1 / 171700
• WormBaseID: WBGene00021685
• Length: 1019
• Species: Caenorhabditis elegans
• Alignment Length: 967
• Identity: 239/967 - (24%)
• Similarity: 372/967 - (38%)
• Gaps: 274/967 - (28%)

Human    11 SGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCG--NEACTNE------FCASCPTF------- 60
            |||...||:.    .:.:.:|:     ||: :|.|  ..||.:.      .|....:|
 Worm   219 SGELGIDDLR----PQTSVQHV-----HQM-DGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQ 273

Human    61 ------LRMDNNAAAIKAL---ELYKINAKLCDPHPSKKGASSAYLENSKGAPNN---------- 106
                  :....|..|:..|   .:.:|.|..|......|||...:..||.|...|
 Worm   274 CGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAPYPFGLNSSGQLGNGKIMTQSTPR 338

Human   107 ----------------------SCSEIKMNK-KGARIDFKDVTYLTEEKVYEILELCREREDYSP 148
                                  |...|:.|: .|.....:....|..|.:.::|    :..|...
 Worm   339 KTDELDHVTGVFAGYHQTFFVRSSGTIEQNEIVGPSCPMQYPIKLDHESLKKLL----DEGDALE 399

Human   149 LIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSR 213
            ::.:|..||||..::..||..                  |||.......|.
 Worm   400 VMSLIESVFSSLASMNMSFLY------------------KDERRYNVGFCF-------------- 432

Human   214 IGDSSQGDNNLQKLGPDDVSVDIDAI------------RRVYTRLLSNEKIETAFLNALVYLSPN 266
              :.|.|             :|:|.:            :|.|..|:. :.::.||......|. .
 Worm   433 --ERSHG-------------IDMDQVMEAFMLFDEYPMKRQYMELIV-DSLKIAFQEWSENLK-G 480

Human   267 VEC-----DLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIR 326
            :||     .|.:..:::.:.|       |...:|:|:|         |..||..:....:..|.:
 Worm   481 IECLRVLLMLPWLPIFTENVN-------VQTIKNVHTP---------FVDAMCLITGDLRAALEK 529

Human   327 LWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTN 391
            .|::.:....|||:..|:                     .||.|..|.
 Worm   530 WWTQLSTRHFRRMVTVFK---------------------TAIKAMLKA----------------- 556

Human   392 HNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRK--------------- 441
                                        |||||             ||.|
 Worm   557 ----------------------------KKGPR-------------DCHKFILIMQKLSLINKTY 580

Human   442 PLIPFEEFINEPLNEVLEMDKDYTF-------FKVETENKFSFMTCPFILNAVTKNLGLYYDNRI 499
            .:||.|.|..:.||..:::..:|..       .|.|.:....|   ||:||.|.|...::.:..:
 Worm   581 HIIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHF---PFLLNGVAKGELIFVEAWL 642

Human   500 RMYSERRITVLYSLVQGQQL--NPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGE 562
             |.:.||.:.|::...|..:  .|:|.|.|||:.|:.|.   :..:|..:.:||:|.|.|...||
 Worm   643 -MQTLRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDT---MNQMAGLSESDLQKPLKVNIAGE 703

Human   563 QGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN--PSSFETEGQFTLIGIVLGLAIYN 625
            ...|.|||.||||.||:.:|...|.|||:.||.:.|.||:  ||.|....||..:|.::||:|||
 Worm   704 DADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYN 768

Human   626 NCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDDMMITFQISQTDLFG 689
            :.|:...||:.:|:.|:.......||.:..|...:.||.||.| |.:|||...:.|.|| .::.|
 Worm   769 HSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCIS-FNILG 832

Human   690 NPMMYDLKENGDKIPITNENRKEFVNLYSDYIL----NKSVEKQFKAFRRGFHMVTNESPLKYLF 750
            .....:|...|.:.|:||.||.|:|.||..:.|    |..:.:|...||:||....:...|:: |
 Worm   833 ETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRF-F 896

Human   751 RPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRA 815
            :|.|::.:|.|:.|.|:....:...|.|.|:.....|:.||:...:.||:::|.||||.||:.|.
 Worm   897 QPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRI 961

Human   816 PVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
            ||.|..:|...|..:.|  |.||.:|||||:|.||..:...:|..||..:|.:.:||
 Worm   962 PVSGWEELHAAIQPSAP--ESLPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGF 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862	14/77 (18%)
		HECTc	523..873	CDD:238033	132/357 (37%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511	27/149 (18%)
		HECTc	667..1016	CDD:238033	130/355 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020