DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment UBE2H and CG14739

DIOPT Version :9

Sequence 1:	NP_003335.1	Gene:	UBE2H / 7328	HGNCID:	12484	Length:	183	Species:	Homo sapiens
Sequence 2:	NP_650151.1	Gene:	CG14739 / 41467	FlyBaseID:	FBgn0037987	Length:	206	Species:	Drosophila melanogaster

Alignment Length:	180	Identity:	75/180 - (41%)
Similarity:	106/180 - (58%)	Gaps:	4/180 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     4 PSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSI 68
            |..| ||:|.||.:|:.|.:..|:...:....|...||.|:.||||:|.|.|.:|..||..:|.:
  Fly    12 PMAG-RRLDRDVNRLLASGYRTTVDDDMTNLNVCLEGPLGSAYEGGIWTVNVTMPQDYPLTAPRV 75

Human    69 GFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHR 133
            .|:.||.||||:..:|.||::|:.|.|::.|||.||||:||||||.||||.|.||..|||:..|.
  Fly    76 RFVTKILHPNIEFITGLVCMNVLKQAWSSSYDLVNIFETFLPQLLRYPNPHDSLNHRAAAIMKHS 140

Human   134 PEEYKQKIKEYIQKYATEEALKEQ---EEGTGDSSSESSMSDFSEDEAQD 180
            .:.:::.:...::.||....|..:   |||....||:.|:||...|...|
  Fly   141 EQLFREHVILCMKTYAMPANLPTRQLVEEGLEKRSSDLSLSDLLTDSDDD 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE2H	NP_003335.1	UQ_con	31..145	CDD:395127	52/113 (46%)
UBE2H	NP_003335.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..183		11/32 (34%)
CG14739	NP_650151.1	COG5078	12..157	CDD:227410	63/145 (43%)
CG14739	NP_650151.1	UQ_con	17..152	CDD:278603	59/134 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0416
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S325
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1301162at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.730