Protein Alignment UBE2D2 and UbcE2M

DIOPT Version :10

• Sequence 1: XP_047273646.1
• Gene: UBE2D2 / 7322
• HGNCID: 12475
• Length: 173
• Species: Homo sapiens
• Sequence 2: NP_648187.1
• Gene: UbcE2M / 38916
• FlyBaseID: FBgn0035853
• Length: 181
• Species: Drosophila melanogaster
• Alignment Length: 743
• Identity: 134/743 - (18%)
• Similarity: 235/743 - (31%)
• Gaps: 252/743 - (33%)

Human  1171 SYNYRVVKEIL---IRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAED---T 1229
            ||.:.:.|.::   ..:.:|..:....:||.::::.|.|:.:|...|.|..::....:..|   .
  Fly    25 SYTHNLEKNLVALETTMEELKAKRDDLLRKLKREEDRGLQTLGEIKVWLNRVETIESRVNDLLNA 89

Human  1230 KMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNP------GILEAVTMQHIFMNNFQLCSEI 1288
            :..|:.||.   |..||:.:........|.:.|.|..      .:.|.::.|       ...||:
  Fly    90 RNAELQRLC---LCGFCSKSLTTSYRYGKSVFLKLREVEKLERRVFEVISDQ-------ASTSEV 144

Human  1289 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQ 1353
            .|:.:|                   .|||..|...     |.....|:..|..::..|.
  Fly   145 EEQQLQ-------------------PTIVGQETML-----DNAWNHLMEDGVGIMGLYG------ 179

Human  1354 TLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPE 1418
                               |..:....||   |:..|.:::..|.    .|.::.||..:    |
  Fly   180 -------------------MGGVGKTTLL---TQINNKFSKYMCG----FDSVIWVVVSK----E 214

Human  1419 VKIAYI--NFLNHCYV-----DTEVE-MKEIYTSNHMWKL-FENFLVDICRACNNTSDRKHADSI 1474
            |.:..|  ......::     ||:.: .|.:|..|.:.|: |..||.||....|
  Fly   215 VNVENILDEIAQKVHISGEKWDTKYKYQKGVYLYNFLRKMRFVLFLDDIWEKVN----------- 268

Human  1475 LEKYVTEIVMSIVT------TFFSSPFSDQSTTLQTRQPVFVQLL--QGVFRVYHCNWLMPSQK- 1530
                :.||.:...|      ..|::...|..|::...:|:.||.|  ...:.::        ||
  Fly   269 ----LVEIGVPFPTIKNKCKVVFTTRSLDVCTSMGVEKPMEVQCLADNDAYDLF--------QKK 321

Human  1531 -----ASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSV 1590
                 ...:..||.||.|...:...:|:.|:.....:..|      :|...||.:.
  Fly   322 VGQITLGSDPEIRELSRVVAKKCCGLPLALNVVSETMSCK------RTVQEWRHAI--------- 371

Human  1591 LAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPEL--------LFPENTDARR-- 1645
                    .::.......|.::|::.||    |....|.|...::        ||||:...|:
  Fly   372 --------YVLNSYAAKFSGMDDKILPL----LKYSYDSLKGEDVKMCLLYCALFPEDAKIRKEN 424

Human  1646 ------------------KCESGGF--ICKLIKHTKQLLEENE---------------------- 1668
                              |.|:.|:  |..|:: ...|:||.|
  Fly   425 LIEYWICEEIIDGSEGIDKAENQGYEIIGSLVR-ASLLMEEVELDGANIVCLHDVVREMALWIAS 488

Human  1669 ------EKLCIKVLQTLREMMTKDRGYGEKLISI---------DELDNAELP----PAPDSENAT 1714
                  |...::....|||::..:.....:.:|:         ..||..||.    .:...|..:
  Fly   489 DLGKQNEAFIVRASVGLREILKVENWNVVRRMSLMKNNIAHLDGRLDCMELTTLLLQSTHLEKIS 553

Human  1715 EQELEPSPPLRQLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGG 1779
            .:.....|.|..|:           |...||.:..|:|..| |.|.....||:
  Fly   554 SEFFNSMPKLAVLD-----------LSGNYYLSELPNGISE-LVSLQYLNLSS------------ 594

Human  1780 SGSSSMSRGEMSLAEVQCHLDKEGASNL 1807
            :|...:.:|...|.:: .||..|..|.|
  Fly   595 TGIRHLPKGLQELKKL-IHLYLERTSQL 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE2D2	XP_047273646.1	UBCc_UBE2D	35..171	CDD:467412
UbcE2M	NP_648187.1	UBCc_UBE2F_UBE2M	26..163	CDD:467414	31/170 (18%)