Protein Alignment UBA7 and Uba3

DIOPT Version :10

• Sequence 1: NP_003326.2
• Gene: UBA7 / 7318
• HGNCID: 12471
• Length: 1012
• Species: Homo sapiens
• Sequence 2: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Alignment Length: 650
• Identity: 136/650 - (20%)
• Similarity: 200/650 - (30%)
• Gaps: 266/650 - (40%)

Human   396 PEDGELLPSPEDCALRG-SRYDGQIAVFG-AGFQEKLR----RQHYLLVGAGAIGCELLKVFALV 454
            |..|.:|.|.....||. ...:|.....| |...|.|.    :...|::|||.:||||||..||:
  Fly     6 PNPGLILQSKRFNGLRNILEREGPFCKDGFAASSENLEFLQTKCQVLIIGAGGLGCELLKDLALM 70

Human   455 GLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPT 519
            |.     |.|.|:|||.||.|||:||||||..|:|..|||.||.......|..:|.|
  Fly    71 GF-----GNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTP-------- 122

Human   520 TEHI-----YGDNFFSRVDGVAAALDSFQARRYVAARCTHYLK-------------PLLEAGTSG 566
              |.     :.::|:.:...|...|||..|||::.......|:             |:::.||.|
  Fly   123 --HFKKIQDFDESFYQQFHLVVCGLDSIVARRWINGMLLSMLRYEEDGTIDTSSIVPMIDGGTEG 185

Human   567 TWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHTLQWARHEFEELFRLSAETIN 631
            ..|:|.|.:|..|............: ..||:||:...|...||.:::.:
  Fly   186 FKGNARVILPGFTACIECTLDLFPPQ-VNYPLCTIANTPRLPEHCIEYVK--------------- 234

Human   632 HHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNK 696
                                                 .:.|
  Fly   235 -------------------------------------IIQW------------------------ 238

Human   697 VLEDGTPFWSGPKQCPQPLEFDTNQDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPD 761
              |...||                                   |:|              |...|
  Fly   239 --EKQNPF-----------------------------------GVP--------------LDGDD 252

Human   762 PQQMAPIFASNLELASASAEFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAAS 826
            ||                                                     |:.::...|.
  Fly   253 PQ-----------------------------------------------------HIGWIYERAL 264

Human   827 LRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAEN 891
            .|...:.|..|.....:.:|..||||:|:|.||:|....||::|:.:.              ..:
  Fly   265 ERSNEFNITGVTYRLVQGVVKHIIPAVASTNAAIAAACALEVFKLATS--------------CYD 315

Human   892 YLIRYMPF--APAIQTFHHLKWTSWDRL-------KVPAGQPE-RTLESLLAHLQEQHGLRVRIL 946
            .:..|:.|  ...|.|:.:....|.:.|       .:|...|. .|||.::..|.:.    .|..
  Fly   316 SMANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPNTTTLEDVIKLLCDS----PRFQ 376

Human   947 LHGSAL-----------LYAAGWSPEKQA--QHLPLRVTEL----VQQLT-GQAPAPGQRVLVLE 993
            |...||           ||.:|....::|  ::|...:.||    .|||| ..|.:|....|.|:
  Fly   377 LKSPALTTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTLQLK 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBA7	NP_003326.2	Ube1	10..1010	CDD:273603	136/649 (21%)
		2 approximate repeats	23..575		68/202 (34%)
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	100/505 (20%)
		E2_bind	357..442	CDD:462611	24/88 (27%)