Protein Alignment UBA7 and Uba1

DIOPT Version :10

• Sequence 1: NP_003326.2
• Gene: UBA7 / 7318
• HGNCID: 12471
• Length: 1012
• Species: Homo sapiens
• Sequence 2: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Alignment Length: 1021
• Identity: 418/1021 - (40%)
• Similarity: 608/1021 - (59%)
• Gaps: 43/1021 - (4%)

Human    10 LDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAA 74
            :||.||||||||||..||:|:..:.:|:|||.|||.|:|||::|.||.|:||||.......||::
  Fly   195 IDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSS 259

Human    75 QFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDITEDLLLDFQVVVLTAAKLEEQLKVGTLC 139
            ||.|:|.|:.::|||||...||:||..|:.|.|||.:||:.|..|:|||||.:..|||.::....
  Fly   260 QFYLTEADIGKNRAEASCAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQRIAKFA 324

Human   140 HKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAAIQHISQGSPGILTLRKGANTHYFR 204
            |::|:..:.|:||||..::||||||.||:.|....:|::..|..|:..:.|::|. .....|.|.
  Fly   325 HENGIALIIAETRGLFAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTC-LDETRHGFN 388

Human   205 DGDLVTFSGIEGMVELNDCDPRSIHVREDGSLEIGDTTTFSRYLRGGAITEVKRPKTVRHKSLDT 269
            |||.||||.::||.|||.|.|..|.|....:..||||:.|..|..||..|:||.|||:..|.|..
  Fly   389 DGDYVTFSEVQGMQELNGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQ 453

Human   270 ALLQPHVVAQSSQEVHHAHCLHQAFCALHKFQHLH-GRPPQPWDPVDAETVVGLARDLEPLKRTE 333
            |..:|..:.....::.....||.||.||..::..| |..|:||:..||.:.:.:.|
  Fly   454 ATEEPEFLISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLEVVR--------- 509

Human   334 EEPLEEPLDEALVRTVALSSAGVLSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDALDCLPED 398
             ......:||.||...|...:|...|:.|.:|.:.|||||||.|.||.|:.||||||||:|||.:
  Fly   510 -ASSNAEVDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLPTE 573

Human   399 GELLPSPEDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGG 463
            |   ....|....|||||.|||:||..|||||....:.:||||||||||||.|.::|||.|| |.
  Fly   574 G---VEEADAQPVGSRYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTGN-GQ 634

Human   464 LTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNF 528
            :.|.|||.||:|||:||||||..||.:||:..||.|.:.:||::.|......:...||.::.::|
  Fly   635 IFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDF 699

Human   529 FSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASED 593
            |.::||||.|||:..||.|:..:|.....||:|.||.||.|:..|.:|..||:|      ::|:|
  Fly   700 FGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESY------SSSQD 758

Human   594 AP---YPVCTVRYFPSTAEHTLQWARHEFEELFRLSAETINHH---QQAHTSLADMDEPQTLTLL 652
            .|   .|:||::.||:..||||||||..||.:|:.|||....:   .|....:|.:...|.|.:|
  Fly   759 PPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEIL 823

Human   653 KPV-LGVLRVRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTPFWSGPKQCPQPLE 716
            ..: ..::..:|:::..||.||..:|:..:...|||||.:|||:::...|.|||||||:||.||.
  Fly   824 DSIKKALIDDKPKSFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLV 888

Human   717 FDTNQDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPD--PQQMAPIFASNLELASAS 779
            ||.|...||.::.|||||.|:::|:...::...:.||::.:..|:  |:....| .:|...|:||
  Fly   889 FDVNDPMHLDFIYAAANLRAEVYGIEQVRNRETIAELVQKVKVPEFKPRSGVKI-ETNEAAAAAS 952

Human   780 A------EFGPEQ-QKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPV 837
            |      |...:: .|.:::.|:.......:.||.||||||||.|:||:||.::||..||.|||.
  Fly   953 ANNFDDGELDQDRVDKIISELLKNADKSSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPA 1017

Human   838 NRAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFAPA 902
            :|.:||.|.|:|||||||||:.::||..||:.|::.|.|....|::.:.:||..::....|...|
  Fly  1018 DRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAA 1082

Human   903 IQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQEQHGLRVRILLHGSALLYAAGWSPEKQAQHL 967
            ..|::..:||.|||.:|..   |.:|:..|.:.:|...|::.:|..|.::||:......|.::.|
  Fly  1083 KNTYYGKEWTLWDRFEVTG---ELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERL 1144

Human   968 PLRVTELVQQLTGQAPAPGQRVLVLELSC-EGDDEDTAFPPLHYEL 1012
            ||.::|:|::::.:...|.:|.||.|:.| :.|.||...|.:.|.|
  Fly  1145 PLPMSEVVRRVSKRRLEPHERSLVFEICCNDVDGEDVEVPYVRYTL 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBA7	NP_003326.2	Ube1	10..1010	CDD:273603	416/1017 (41%)
		2 approximate repeats	23..575		243/552 (44%)
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	416/1017 (41%)