DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a23 and CG33233

DIOPT Version :9

Sequence 1:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	93/460 - (20%)
Similarity:	177/460 - (38%)	Gaps:	104/460 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse   230 SLLVGLIFGYLITGCIADWVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLA---- 290
            |||.|::...|..|.:||..||:.|:..:.:..|.|.:..||..::...|.:|...|..|:
  Fly    64 SLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVAS 128

Mouse   291 ---GIILTLYALR-----IELCPPGKRFIITMVASFVAMAGQFLMPG-----LAAL--CRDWQVL 340
               |.:...:|::     :.:|...:...: :....||||   ::|.     |::.  .|.|:.|
  Fly   129 LQVGFLGEFHAIKWRPITVAICSQSQGLAL-IYCPLVAMA---ILPNNFNVDLSSSYNLRVWRFL 189

Mouse   341 QALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKN---------CVSPE----SD 392
            ....:.|..|.|:...:.||:..:||:..:.:.|...:.::.:.|         .:|.|    :|
  Fly   190 MMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTND 254

Mouse   393 IKGVMPEL---EKELSRRPKK----VCIVKVVGT------RNLWKNIV---------VLC--VNS 433
            .:|....:   .|.|..:|..    :|:..:.|.      ..:|..::         .||  ||:
  Fly   255 QEGFWKTVWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVNN 319

Mouse   434 LTGYGIHHCFARSMMGHEVKVP--------LLENFYADYYTMASIALASCLAMCLVVKFLGRRGG 490
            ...:..|.  |....|.:.:.|        |::..|..:..:....|||.|...:..|::
  Fly   320 NPTFINHE--ADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASVLVHWMTRKYV----- 377

Mouse   491 LLLFMILTALASLLQLGL-LNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAV 554
                :.|..|.|:: ||: ||::    :.|...|                  .|.::.|.....:
  Fly   378 ----IALHILISMI-LGISLNIM----KQPTVVL------------------IFFVLMMVLPGVL 415

Mouse   555 GSLSVFFCAEITPTVIRCGGLGLVLASAGF-GMLTAPIIELHNQKGYFLHHIIFACCTLICIICI 618
            ..|:.....:..|..:|...|.:|.:.|.| |:|.:.:|.|..:....:...||..|..||::..
  Fly   416 IPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTFNIFNLCLAICVVLA 480

Mouse   619 LLLPE 623
            :..|:
  Fly   481 VFQPK 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		2A0119	98..631	CDD:273328	93/460 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188
		MFS	230..>359	CDD:119392	34/147 (23%)
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	85/424 (20%)
		MFS	23..>208	CDD:119392	34/147 (23%)
		MFS	354..>482	CDD:304372	32/159 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843334
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930