DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and dpr6

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	74/343 - (21%)
Similarity:	118/343 - (34%)	Gaps:	104/343 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    31 ASLLLPESAAAGL---KLM------GAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKD------- 79
            |:||||.:..|..   |.|      ..|..:|...|:...|:|.|..:....:.|::.
  Fly    53 AALLLPTAPTAAYTHPKWMEPYFDPSTPRNVTALMGKSAYLSCRVRNLANKTVSWIRHRDIHILT 117

Human    80 -GAVVQNLDQLYIPVSEQ---HWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPV--------- 131
             |:.....||.:.....|   .|.  |.:|..::.|||.|.||:.       :|||
  Fly   118 VGSYTYTSDQRFQATHHQDTEDWT--LQIKWAQKRDAGMYECQIS-------TQPVRSYFVRLNV 173

Human   132 ---WLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWW------------RG----T 177
               ..|:.|.|       ||.|...:...|:|.....|||...::|            ||    .
  Fly   174 VVPTATILGGP-------DLHVDKGSTINLTCTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVI 231

Human   178 TKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNAS 242
            |:.|....|..::....:..|..:||...|    |...:..||:         :.|..:.|....
  Fly   232 TEKGDVTTSFLLIQNADLADSGKYSCAPSN----ADVASVRVHV---------LNVRAIISGEHP 283

Human   243 VAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPS 307
            .|...|:.|      |..       .|  |.:|:.:....|          ||.: :|::|: |:
  Fly   284 EAMQTGSSG------CQY-------NW--LTIVLLLGLVLC----------YSSQ-QCSSAV-PA 321

Human   308 PYADWVPFQTKGLAPASA 325
            .....:|..::...||:|
  Fly   322 SLTSSLPLPSQLPLPAAA 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	23/108 (21%)
		IGc2	56..121	CDD:197706	18/75 (24%)
		Ig2_Tyro3_like	141..220	CDD:143226	19/94 (20%)
		IG_like	145..220	CDD:214653	19/90 (21%)
		FN3	225..317	CDD:238020	16/91 (18%)
		fn3	324..406	CDD:278470	1/2 (50%)
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	23/103 (22%)
		IG_like	80..175	CDD:214653	23/103 (22%)
		IG_like	184..271	CDD:214653	21/97 (22%)
		IGc2	191..262	CDD:197706	15/74 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910