DRSC/TRiP Functional Genomics Resources

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Protein Alignment TYRO3 and Eph

DIOPT Version :10

Sequence 1:NP_006284.2 Gene:TYRO3 / 7301 HGNCID:12446 Length:890 Species:Homo sapiens
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:686 Identity:178/686 - (25%)
Similarity:285/686 - (41%) Gaps:164/686 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   225 PAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVV----VPVPPFT--- 282
            ||||.|:|:..:..::|.::|...|...:.......::..:...:::...:    |...|.|   
  Fly   387 PAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTF 451

Human   283 ----CLLRDLVPATNYSLRVRCANALGP-------------SPYADWVPFQTKGLAPASAPQNLH 330
                ..|.:|.|.|.|::::...|::..             ...:|.|...|..|   :.|.:|:
  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLL---NIPLDLN 513

Human   331 AIRTDSGLI--------------------------LEWEEVIPEAPLEGPLGPYKLSWVQ----D 365
            .::|....|                          |||::.:..   :.||..|::.|..    |
  Fly   514 EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS---DFPLEFYEVRWFPKVELD 575

Human   366 NGTQDELTVEGTRANLTGWDPQKDLIVRV-CVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSW 429
            ...:..|..:.|:|::.|.....:...:| |.:|. |.|.:|..:...:....|.......:..:
  Fly   576 AINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN-GFGSYSNMIYAQTLQSVGSVYDDSVQIRF 639

Human   430 V--PVVLGVLTALVTAAALALILLRKR-----RKETR---------------------------- 459
            :  .:|.|||..::...|....:..|.     :|.|.                            
  Fly   640 IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLN 704

Human   460 -----FGQAFDSVMARGEPAVH---FRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQ 516
                 ||.:...|    :|..:   .:|.|.|.||                          |...
  Fly   705 VTTPLFGNSRSYV----DPHTYEDPNQAIREFARE--------------------------IDAN 739

Human   517 QFTLGRMLGKGEFGSVREAQLKQEDGSFVK---VAVKMLKADIIASSDIE--EFLREAACMKEFD 576
            ..|:..::|.||||.|...:||... :||:   ||:|.||.   .||:..  :||.||:.|.:||
  Fly   740 YITIEAIIGGGEFGDVCRGRLKIPP-NFVQDIDVAIKTLKP---GSSEKARCDFLTEASIMGQFD 800

Human   577 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQT--LIRFMVDI 639
            ||:|..|.||..||.     |: |:|..:|::|.|..||   |:.:..|    ||  ||..:..|
  Fly   801 HPNVIYLQGVVTRSN-----PV-MIITEYMENGSLDTFL---RVNDGKF----QTLQLIVMLRGI 852

Human   640 ACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI--YSGDYYRQGCASKLPVKWLALE 702
            |.||.|||..|::||||||||.::...:...:|||||||:|  .|..|..:|  .|:||:|.|.|
  Fly   853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG--GKIPVRWTAPE 915

Human   703 SLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQ 767
            ::|...:|..||||::||.:||:|:.|:.||....|.::...:..|.||..|.:|.|.:|.||..
  Fly   916 AIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLD 980

Human   768 CWSADPKQRPSFTCLRMELENILGQ-LSVLSASQDP 802
            ||......||:|..:...|:|:..| .|:|:....|
  Fly   981 CWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSP 1016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TYRO3NP_006284.2 Ig1_Tyro3_like 50..136 CDD:409553
Ig strand A 50..55 CDD:409553
Ig strand B 58..67 CDD:409553
Ig strand C 73..78 CDD:409553
Ig strand C' 81..83 CDD:409553
Ig strand D 87..92 CDD:409553
Ig strand E 97..104 CDD:409553
Ig strand F 113..119 CDD:409553
Ig strand G 125..136 CDD:409553
IgI_2_Axl_Tyro3_like 140..220 CDD:409407
Ig strand A 140..143 CDD:409407
Ig strand A' 146..150 CDD:409407
Ig strand B 154..163 CDD:409407
Ig strand C 168..175 CDD:409407
Ig strand C' 177..180 CDD:409407
Ig strand E 184..195 CDD:409407
Ig strand F 198..207 CDD:409407
Ig strand G 211..220 CDD:409407
FN3 225..317 CDD:238020 20/115 (17%)
fn3 324..406 CDD:394996 21/112 (19%)
PTKc_Tyro3 508..791 CDD:270659 112/291 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..837
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..871
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 17/88 (19%)
FN3 536..623 CDD:238020 18/90 (20%)
EphA2_TM 640..738 CDD:464211 18/127 (14%)
PTKc_EphR 736..1002 CDD:270629 111/284 (39%)
SAM_1 1029..1092 CDD:425739
Blue background indicates that the domain is not in the aligned region.

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