DRSC/TRiP Functional Genomics Resources

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Protein Alignment TYRO3 and Eph

DIOPT Version :9

Sequence 1:NP_006284.2 Gene:TYRO3 / 7301 HGNCID:12446 Length:890 Species:Homo sapiens
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:686 Identity:178/686 - (25%)
Similarity:285/686 - (41%) Gaps:164/686 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   225 PAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVV----VPVPPFT--- 282
            ||||.|:|:..:..::|.::|...|...:.......::..:...:::...:    |...|.|   
  Fly   387 PAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTF 451

Human   283 ----CLLRDLVPATNYSLRVRCANALGP-------------SPYADWVPFQTKGLAPASAPQNLH 330
                ..|.:|.|.|.|::::...|::..             ...:|.|...|..|   :.|.:|:
  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLL---NIPLDLN 513

Human   331 AIRTDSGLI--------------------------LEWEEVIPEAPLEGPLGPYKLSWVQ----D 365
            .::|....|                          |||::.:..   :.||..|::.|..    |
  Fly   514 EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS---DFPLEFYEVRWFPKVELD 575

Human   366 NGTQDELTVEGTRANLTGWDPQKDLIVRV-CVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSW 429
            ...:..|..:.|:|::.|.....:...:| |.:|. |.|.:|..:...:....|.......:..:
  Fly   576 AINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN-GFGSYSNMIYAQTLQSVGSVYDDSVQIRF 639

Human   430 V--PVVLGVLTALVTAAALALILLRKR-----RKETR---------------------------- 459
            :  .:|.|||..::...|....:..|.     :|.|.                            
  Fly   640 IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLN 704

Human   460 -----FGQAFDSVMARGEPAVH---FRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQ 516
                 ||.:...|    :|..:   .:|.|.|.||                          |...
  Fly   705 VTTPLFGNSRSYV----DPHTYEDPNQAIREFARE--------------------------IDAN 739

Human   517 QFTLGRMLGKGEFGSVREAQLKQEDGSFVK---VAVKMLKADIIASSDIE--EFLREAACMKEFD 576
            ..|:..::|.||||.|...:||... :||:   ||:|.||.   .||:..  :||.||:.|.:||
  Fly   740 YITIEAIIGGGEFGDVCRGRLKIPP-NFVQDIDVAIKTLKP---GSSEKARCDFLTEASIMGQFD 800

Human   577 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQT--LIRFMVDI 639
            ||:|..|.||..||.     |: |:|..:|::|.|..||   |:.:..|    ||  ||..:..|
  Fly   801 HPNVIYLQGVVTRSN-----PV-MIITEYMENGSLDTFL---RVNDGKF----QTLQLIVMLRGI 852

Human   640 ACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI--YSGDYYRQGCASKLPVKWLALE 702
            |.||.|||..|::||||||||.::...:...:|||||||:|  .|..|..:|  .|:||:|.|.|
  Fly   853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG--GKIPVRWTAPE 915

Human   703 SLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQ 767
            ::|...:|..||||::||.:||:|:.|:.||....|.::...:..|.||..|.:|.|.:|.||..
  Fly   916 AIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLD 980

Human   768 CWSADPKQRPSFTCLRMELENILGQ-LSVLSASQDP 802
            ||......||:|..:...|:|:..| .|:|:....|
  Fly   981 CWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSP 1016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TYRO3NP_006284.2 IG_like 49..135 CDD:214653
IGc2 56..121 CDD:197706
Ig2_Tyro3_like 141..220 CDD:143226
IG_like 145..220 CDD:214653
FN3 225..317 CDD:238020 20/115 (17%)
fn3 324..406 CDD:278470 21/112 (19%)
PTKc_Tyro3 508..791 CDD:270659 112/291 (38%)
Pkinase_Tyr 518..786 CDD:285015 109/276 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..837
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..871
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 17/88 (19%)
FN3 536..623 CDD:238020 18/90 (20%)
EphA2_TM 644..736 CDD:291255 17/121 (14%)
PTKc_EphR 736..1002 CDD:270629 111/284 (39%)
Pkinase_Tyr 741..999 CDD:285015 109/276 (39%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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