DRSC/TRiP Functional Genomics Resources

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Protein Alignment TYRO3 and InR

DIOPT Version :9

Sequence 1:NP_006284.2 Gene:TYRO3 / 7301 HGNCID:12446 Length:890 Species:Homo sapiens
Sequence 2:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster


Alignment Length:285 Identity:111/285 - (38%)
Similarity:165/285 - (57%) Gaps:31/285 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   524 LGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIE--EFLREAACMKEFDHPHVAKLV 584
            ||:|.||.|.|..||.  .:|...:.|:|.:..:   ::|.|  .||.||:.|||||..||.:|:
  Fly  1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNEN---ATDRERTNFLSEASVMKEFDTYHVVRLL 1438

Human   585 GVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA--------------SRIGENPFNLPLQT---L 632
            ||..|.:.      .:|::..||.|||.::|.|              :|||... |:...|   :
  Fly  1439 GVCSRGQP------ALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTG-NVQPPTYGRI 1496

Human   633 IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK 697
            .:..::||.||.||:::.|:||||||||||:|:|:||.:.|||::|.||..||||:|....|||:
  Fly  1497 YQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVR 1561

Human   698 WLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVY 762
            |:..|||.|.:|:..|||::|||.:||:.|....||.|:.|.::..|:|.|..:::|..|.:.::
  Fly  1562 WMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLH 1626

Human   763 DLMYQCWSADPKQRPSFTCLRMELE 787
            .||.:||......||||..:...||
  Fly  1627 KLMQRCWHHRSSARPSFLDIIAYLE 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TYRO3NP_006284.2 IG_like 49..135 CDD:214653
IGc2 56..121 CDD:197706
Ig2_Tyro3_like 141..220 CDD:143226
IG_like 145..220 CDD:214653
FN3 225..317 CDD:238020
fn3 324..406 CDD:278470
PTKc_Tyro3 508..791 CDD:270659 111/285 (39%)
Pkinase_Tyr 518..786 CDD:285015 109/282 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..837
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..871
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382
Furin-like 512..645 CDD:279142
FU 545..592 CDD:238021
Recep_L_domain 663..781 CDD:279382
FN3 1224..1302 CDD:238020
PTKc_InsR_like 1364..1652 CDD:173625 111/285 (39%)
Pkinase_Tyr 1371..1650 CDD:285015 109/282 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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