DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and htl

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	199/823 - (24%)
Similarity:	303/823 - (36%)	Gaps:	277/823 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    49 PVKLTVSQGQP----VKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVER 109
            |.|::..|.:|    :.|||...|..||:|.|.::|.|  :..:.|..:....|.  |:::.:..
  Fly   106 PKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTV--DWTRGYGSLKRNRWT--LTMEDLVP 166

Human   110 SDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWW 174
            .|.|.|.|:|                                        |.::|
  Fly   167 GDCGNYTCKV----------------------------------------CNSLG---------- 181

Human   175 RGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSS 239
                                        |..|:.:.:.|.|..  |...|...|.|:|:...|:.
  Fly   182 ----------------------------CIRHDTQVIVSDRVN--HKPILMTGPLNLTLVVNSTG 216

Human   240 NASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANAL 304
            :....::.....:.              .|    :.||....|                .|:|
  Fly   217 SMHCKYLSDLTSKK--------------AW----IFVPCHGMT----------------NCSN-- 245

Human   305 GPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQ 369
                                   |...|..|                                 :
  Fly   246 -----------------------NRSIIAED---------------------------------K 254

Human   370 DELTVEGTRANLTGWDPQKDLIVRVCV-SNAVGCGPWSQPL--VVSSH--DRAGQQGPPHSRTSW 429
            |:|.....|....||        ..|| ||::|....:..|  |.|.|  :.....|..|| ||:
  Fly   255 DQLDFVNVRMEQEGW--------YTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHS-TSF 310

Human   430 VPV-VLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEA 493
            |.: |.|.|..:..........:||.:.|....|..::|....:..:.|:.            |.
  Fly   311 VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKP------------EG 363

Human   494 TLDSLGISD-------ELKEKLEDVL---------------------IPEQQFTLGRMLGKGEFG 530
            ..||.|..|       .::::...||                     :|.....||..||:|.||
  Fly   364 GGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFG 428

Human   531 SVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD-HPHVAKLVGVSLRSRAKG 594
            .|..|::..     ..|||||:| :.....||...:||...||... |.::..|:|...::   |
  Fly   429 RVVMAEVNN-----AIVAVKMVK-EGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN---G 484

Human   595 RLPIPMVILPFMKHGDLHAFLLASRIGENPFN------------------LPLQTLIRFMVDIAC 641
            .|   .||:.:..||:|..||..:|    ||.                  :..:.||:|...||.
  Fly   485 PL---YVIVEYAPHGNLKDFLYKNR----PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIAR 542

Human   642 GMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLAD 706
            ||:||:||..|||||||||.::::|..:.:|||||:|.|.|.||||:....:||:||:|.|||.:
  Fly   543 GMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQE 607

Human   707 NLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENA-EIYNYLIGGNRLKQPPECMEDVYDLMYQCWS 770
            ..|..:||||::|:.:|||||.||.||..|.:| |:|.||:.|.|:::|.:|..::|.||.|||.
  Fly   608 KFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWH 672

Human   771 ADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEP 813
            .:...||.||    |:...:.:|  |...:|.|.::|...:.|
  Fly   673 FNADDRPPFT----EIVEYMDKL--LQTKEDYLDVDIANLDTP 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	22/89 (25%)
		IGc2	56..121	CDD:197706	20/68 (29%)
		Ig2_Tyro3_like	141..220	CDD:143226	6/78 (8%)
		IG_like	145..220	CDD:214653	6/74 (8%)
		FN3	225..317	CDD:238020	10/91 (11%)
		fn3	324..406	CDD:278470	13/82 (16%)
		PTKc_Tyro3	508..791	CDD:270659	116/323 (36%)
		Pkinase_Tyr	518..786	CDD:285015	112/287 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
htl	NP_524394.2	Ig	112..191	CDD:299845	24/160 (15%)
		IG_like	113..191	CDD:214653	24/159 (15%)
		IG_like	205..289	CDD:214653	24/183 (13%)
		PKc_like	404..692	CDD:304357	115/309 (37%)
		STYKc	416..688	CDD:214568	113/291 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910