DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and Csk

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	653	Identity:	161/653 - (24%)
Similarity:	269/653 - (41%)	Gaps:	169/653 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   183 PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATV------HLQALPAAPFNITVTKLSSSNA 241
            |||:.:.:...|          :.::.|.|::..|..      |||.|...|........||.||
  Fly   514 PAPTVAAVQPAG----------SQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNA 568

Human   242 SVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGP 306
            :...|.||: |||... ::.::.:..|..:|....|.||     :...||....:....:..:..
  Fly   569 AQMGMHGAE-RALPPK-SLALSGSQHGSNMLLHTAPQPP-----QASQPAAVVGVSGSGSAGMST 626

Human   307 SPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYK-----------L 360
            |.::    |...|:...|......|..:.|...:....:.|.|     |.|.:           :
  Fly   627 SLHS----FDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTA-----LAPQQGRSRCEVKLNAM 682

Human   361 SWVQDNGTQDE-------------LTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVS 412
            .|...:.|:||             |..|.|  |..|     |..:.||..:.|
  Fly   683 PWFHGSITRDEAEHLLQPREDGLFLVREST--NFPG-----DYTLCVCFQSKV------------ 728

Human   413 SHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHF 477
                      .|.|..::...|.:...                      :.|:::   |:...|:
  Fly   729 ----------EHYRVKYLENKLTIDDE----------------------EYFENL---GQLVAHY 758

Human   478 RAARSFNRERPERIEATLDSLGISDELKEKLEDV-----------------LIPEQQFTLGRMLG 525
            .|                |:.|:..:|.:.|..:                 :|||.:..|...:|
  Fly   759 EA----------------DADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIG 807

Human   526 KGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRS 590
            |||||.|....|:.|     ||||||||.:    ..:::||.||:.|...:|.::.|.:|:...|
  Fly   808 KGEFGDVMLGILRNE-----KVAVKMLKDE----GAVQKFLAEASVMTTLEHDNLVKFIGLVFTS 863

Human   591 RAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRD 655
            :..      .::..:|..|.|..: |.|| |..  ::..:..|.|..|.|.|||||.::..:|||
  Fly   864 KHL------YLVTEYMSKGSLVDY-LRSR-GRQ--HITKKDQIIFAYDTASGMEYLEAKKVVHRD 918

Human   656 LAARNCMLAEDMTVCVADFGLSR-KIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFG 719
            |||||.:::||....|:||||:| :.|:.|      ..|||:||.|.|:|.:..::.:||:|:||
  Fly   919 LAARNVLISEDCVAKVSDFGLAREECYNLD------VGKLPIKWTAPEALKNGRFSNKSDMWSFG 977

Human   720 VTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRM 784
            :.:|||.:.|:.||..|..|::..::..|.:::.|..|..::|::|.|.|..:|.:||:|..|::
  Fly   978 ILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKV 1042

Human   785 ELE 787
            :|:
  Fly  1043 KLQ 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653
		IGc2	56..121	CDD:197706
		Ig2_Tyro3_like	141..220	CDD:143226	7/42 (17%)
		IG_like	145..220	CDD:214653	7/42 (17%)
		FN3	225..317	CDD:238020	20/91 (22%)
		fn3	324..406	CDD:278470	20/105 (19%)
		PTKc_Tyro3	508..791	CDD:270659	99/298 (33%)
		Pkinase_Tyr	518..786	CDD:285015	94/268 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	24/166 (14%)
		PTKc_Csk_like	793..1047	CDD:270635	98/278 (35%)
		STYKc	800..1044	CDD:214568	94/268 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910