DRSC/TRiP Functional Genomics Resources

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Protein Alignment TYRO3 and Ama

DIOPT Version :9

Sequence 1:NP_006284.2 Gene:TYRO3 / 7301 HGNCID:12446 Length:890 Species:Homo sapiens
Sequence 2:NP_731114.2 Gene:Ama / 40831 FlyBaseID:FBgn0000071 Length:341 Species:Drosophila melanogaster


Alignment Length:370 Identity:86/370 - (23%)
Similarity:141/370 - (38%) Gaps:80/370 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    18 PPPPRLGLLLAALASLLLPESAAAGLKLMGAPV------KLTVSQGQPVKLNCSVEGMEEPDIQW 76
            |...||.||:..:..|.:...:     ::.|||      .:..|.|..|:.||:||.:.:..:.|
  Fly     7 PDMARLRLLIGLIFCLAISLDS-----VLSAPVISQISKDVVASVGDSVEFNCTVEEVGQLSVSW 66

Human    77 VK------DGAVVQNL-------DQLY-IPVSEQHWIG----FLSLKSVERSDAGRYWCQVEDGG 123
            .|      ..:||.::       ||.| :.|:|....|    ...::::|.||.|.|.|||....
  Fly    67 AKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSA 131

Human   124 ETEISQPVWLTVEGVPFFTVE-PKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI---GGPA 184
            ..::::.:.|.::..|..... ||...|......:|:|.|.|.|:| ||.|.|....:   ||..
  Fly   132 TEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPKP-TISWAREHNAVMPAGGHL 195

Human   185 PSPSVLNVTGVTQSTM--FSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMP 247
            .:...|.:..|.:...  :.|.|.|.:|....|...|.::..|         :::.....:|.|.
  Fly   196 LAEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRP---------QIAVQRPKIAQMV 251

Human   248 GADGRALLQSCTVQVTQAPGGWEVLAVVV----PVPPFTCLLRDLVPATNYS------LRVRCAN 302
            ......   .|:||...||       .||    .||..:....::....:.|      ||:   :
  Fly   252 SHSAEL---ECSVQGYPAP-------TVVWHKNGVPLQSSRHHEVANTASSSGTTTSVLRI---D 303

Human   303 ALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIP 347
            ::|...:.|:....|..|..|.|  .||..:|          |||
  Fly   304 SVGEEDFGDYYCNATNKLGHADA--RLHLFQT----------VIP 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TYRO3NP_006284.2 IG_like 49..135 CDD:214653 28/109 (26%)
IGc2 56..121 CDD:197706 24/82 (29%)
Ig2_Tyro3_like 141..220 CDD:143226 22/84 (26%)
IG_like 145..220 CDD:214653 22/79 (28%)
FN3 225..317 CDD:238020 17/101 (17%)
fn3 324..406 CDD:278470 7/24 (29%)
PTKc_Tyro3 508..791 CDD:270659
Pkinase_Tyr 518..786 CDD:285015
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..837
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..871
AmaNP_731114.2 I-set 33..143 CDD:254352 28/109 (26%)
Ig 37..127 CDD:299845 23/89 (26%)
IG_like 154..234 CDD:214653 23/80 (29%)
IGc2 161..223 CDD:197706 17/62 (27%)
I-set 254..330 CDD:254352 19/90 (21%)
IGc2 254..322 CDD:197706 15/80 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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