DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and Ack

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	127/429 - (29%)
Similarity:	189/429 - (44%)	Gaps:	63/429 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   425 SRTSWVPVVLGVLTALVTAAALALIL--LRKRRKETRFGQAFDSVM-------ARGEPAVHFRAA 480
            |.|:|       |..|:....|...|  :|...:.||... ||.|:       ..|:||:. |..
  Fly    13 SETAW-------LEDLLREVQLEQFLDRIRDDLQVTRLAH-FDYVLPDDLERCGLGKPAIR-RLM 68

Human   481 RSFNRERPERIEATLDS--LGISDELKEKLED---------------VLIPEQQFTLGRMLGKGE 528
            .:..:::..:....:.|  :|...:...|.:.               .||.|:..|:|..||.|.
  Fly    69 EAVRKKKAHQWRKNILSKLIGGGKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGS 133

Human   529 FGSVREAQLKQED-GSFVKVAVKMLKADIIASSD-IEEFLREAACMKEFDHPHVAKLVGVSLRSR 591
            ||.||..:..... |..:.||||:||:|.:.... |::|.||...|...||.::.:|.||.|..
  Fly   134 FGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQ- 197

Human   592 AKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDL 656
                 |: |:|....:.|.     |...:.:...:..|..:..:.|.|..||.||..:.|:||||
  Fly   198 -----PM-MMITELAERGS-----LLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDL 251

Human   657 AARNCMLAEDMTVCVADFGLSRKI-YSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV 720
            |.||.:||....:.:.||||.|.: ...|.|......|:|..|.|.|||....::..||.|.|||
  Fly   252 ACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGV 316

Human   721 TMWEIMTRGQTPYAGIENAEIYNYL-IGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRM 784
            |:||:.:.|:.|:.|:..::|...: ..|.||.||..|..|||.:|.|||...|.:||:|..|:.
  Fly   317 TLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKE 381

Human   785 ELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPG 823
            .|           ||..|..:...|:...:.|..:| ||
  Fly   382 YL-----------ASMSPPVMRASRSHHESKGLQIE-PG 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653
		IGc2	56..121	CDD:197706
		Ig2_Tyro3_like	141..220	CDD:143226
		IG_like	145..220	CDD:214653
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659	99/301 (33%)
		Pkinase_Tyr	518..786	CDD:285015	95/271 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	16/69 (23%)
		PTKc_Ack_like	128..385	CDD:270636	94/279 (34%)
		UBA_TNK1	1031..1070	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910