DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and Egfr

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	965	Identity:	218/965 - (22%)
Similarity:	324/965 - (33%)	Gaps:	315/965 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   117 CQVEDGGETEISQPVWLTVEG----VPFFTVEPKDLAVPPN--APFQLSCEAVG-------PPEP 168
            |.|.||....:.|    |..|    ...:|:.|:.:.:.|.  ..|....|..|       .|:.
  Fly   420 CTVIDGNIRILDQ----TFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQF 480

Human   169 VTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQAL--------P 225
            ..:.::|....|.|.....|:.....:.:|:::|.|..|||.::|......|.:.|        |
  Fly   481 RNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWP 545

Human   226 A-------------------APFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEV 271
            |                   ...|.|:.. ...|....|..|.|     |..|.:.....|
  Fly   546 AIQKEPEQKVWVNENLRADLCEKNGTICS-DQCNEDGCWGAGTD-----QCLTCKNFNFNG---- 600

Human   272 LAVVVPVPPFTCL----------------------------------------LRD------LVP 290
                      ||:                                        :||      ..|
  Fly   601 ----------TCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECP 655

Human   291 ATNYSLR-------VRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGL---ILE---- 341
            ...|:.|       ..|....||.        .|.|:. |....||..|..|:.:   :|:
  Fly   656 KNKYNDRGVCRECHATCDGCTGPK--------DTIGIG-ACTTCNLAIINNDATVKRCLLKDDKC 711

Human   342 -----WEEVIPE-----APLEG--------PL--------------------------------- 355
                 ||.|.|:     .||.|        ||
  Fly   712 PDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPAD 776

Human   356 ---------------------GP----------YKLSWVQDNGTQDELTVEGTRANLTGWDPQKD 389
                                 ||          :||....:.|..    |..|..|.|...|
  Fly   777 HYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPY----VNSTMFNCTSKCP--- 834

Human   390 LIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSR--TSWVPV-VLGVLTALVTAAALALILL 451
            |.:|.........||:.            ...||.|.  |:.:.| ::.::|..|....:.::.:
  Fly   835 LEMRHVNYQYTAIGPYC------------AASPPRSSKITANLDVNMIFIITGAVLVPTICILCV 887

Human   452 --------RKRRKET-RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEK 507
                    :|.:||| :...|. |.....||.            ||..|.|.|..|.|
  Fly   888 VTYICRQKQKAKKETVKMTMAL-SGCEDSEPL------------RPSNIGANLCKLRI------- 932

Human   508 LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAV---KMLKADIIASSDIEEFLREA 569
                 :.:.:...|.:||.|.||.|.:.....| |..||:.|   ::||:....||  |||||||
  Fly   933 -----VKDAELRKGGVLGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESS--EEFLREA 989

Human   570 ACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLPLQTL 632
            ..|...:|.::.||:.|.:.|:.       |:|...|..|.|..::..:|  ||.       :.|
  Fly   990 YIMASVEHVNLLKLLAVCMSSQM-------MLITQLMPLGCLLDYVRNNRDKIGS-------KAL 1040

Human   633 IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK 697
            :.:...||.||.||..:..:||||||||.::.....|.:.||||::.:.|.....:....|:|:|
  Fly  1041 LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIK 1105

Human   698 WLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVY 762
            |||||.:.:.::|.:|||||||||:||::|.||.|:..|...:|.:.:..|.:|:||..|..|:|
  Fly  1106 WLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIY 1170

Human   763 DLMYQCWSADPKQRPSFTCLRMELENILGQLS-----VLSASQD-----PLYI-----NIERAEE 812
            ..:..||..|...||:|    .:|..:..:.:     .|:...|     |.|.     ::.|...
  Fly  1171 CTLLSCWHLDAAMRPTF----KQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLA 1231

Human   813 PTAGGSLELPGRD---QPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAE 864
            ||..||..:...|   ||.:..|...........|...||...|.......|..|
  Fly  1232 PTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDE 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	5/17 (29%)
		IGc2	56..121	CDD:197706	2/3 (67%)
		Ig2_Tyro3_like	141..220	CDD:143226	18/87 (21%)
		IG_like	145..220	CDD:214653	17/83 (20%)
		FN3	225..317	CDD:238020	21/163 (13%)
		fn3	324..406	CDD:278470	28/170 (16%)
		PTKc_Tyro3	508..791	CDD:270659	98/287 (34%)
		Pkinase_Tyr	518..786	CDD:285015	97/272 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871		3/14 (21%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	28/130 (22%)
		GF_recep_IV	572..684	CDD:291509	18/139 (13%)
		FU	573..>606	CDD:238021	9/52 (17%)
		FU	617..659	CDD:214589	3/41 (7%)
		FU	662..716	CDD:214589	12/62 (19%)
		FU	739..786	CDD:238021	2/46 (4%)
		FU	784..834	CDD:214589	9/53 (17%)
		PTKc_EGFR_like	930..1208	CDD:270648	101/310 (33%)
		STYKc	938..1194	CDD:214568	98/276 (36%)
		Recep_L_domain	128..239	CDD:279382
		Furin-like	253..401	CDD:279142
		FU	255..292	CDD:214589
		FU	302..345	CDD:238021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910