DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and dpr19

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	225	Identity:	52/225 - (23%)
Similarity:	88/225 - (39%)	Gaps:	51/225 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    60 VKLN--CSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQ---HWIGFLSLKSVERSDAGRYWCQV 119
            ||:|  .:|..:...|.|.:..|....:.|:.::....:   ||  .|.:|:|...|.|.|.||:
  Fly    64 VKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHW--SLRIKAVREEDRGFYECQL 126

Human   120 EDGGETEISQPVWLT---------VEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWR 175
            .          ::.|         ||.|...:..| :|.:...:..:|.|:.....|....|:|.
  Fly   127 S----------IYPTQSIVIELKIVEAVAEISSAP-ELHIDETSTLRLECKLKRATENPAFVFWY 180

Human   176 GTTKI------GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVT 234
            ..:|:      ||       ..||.:.||...|.:.:.......|| ||:.::    :...:..:
  Fly   181 HDSKMINYDSQGG-------FVVTSIGQSNPQSGQFYRSSPANKSR-ATMPME----SSNGVLNS 233

Human   235 KLSSSNASVAWMPGADGRALLQSCTVQVTQ 264
            .|.||:|..|  |.|:    :.|.|..:||
  Fly   234 LLGSSDAIKA--PAAN----VPSSTPYMTQ 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	19/88 (22%)
		IGc2	56..121	CDD:197706	18/65 (28%)
		Ig2_Tyro3_like	141..220	CDD:143226	19/84 (23%)
		IG_like	145..220	CDD:214653	19/80 (24%)
		FN3	225..317	CDD:238020	11/40 (28%)
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	18/64 (28%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	16/62 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910