Protein Alignment TYRO3 and Ror

DIOPT Version :10

• Sequence 1: NP_006284.2
• Gene: TYRO3 / 7301
• HGNCID: 12446
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 134/404 - (33%)
• Similarity: 205/404 - (50%)
• Gaps: 42/404 - (10%)

Human   404 PWSQPLVVSSHDRAGQ--QGPPHSRTSWVPVVLGVLTA--LVTAAALALILLRKRRKETRFGQAF 464
            ||.  .|.||.:|..:  ..|..:...|:.:| |...|  |:.....|:||.::|
  Fly   290 PWC--FVDSSRERIIELCDIPKCADKIWIAIV-GTTAAIILIFIIIFAIILFKRR---------- 341

Human   465 DSVMARGEPAVHFRAARSF------NRERPERIEATLDSLG-ISDE--LKEKL--EDVLIPEQQF 518
             ::|..|...:|.....|.      |.:.....:|...:|| :||.  |..||  .:.|:....|
  Fly   342 -TIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKLIERNTLLRINHF 405

Human   519 TLGRM-----LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
            ||..:     ||:|.||.|.:.||.|.:.:.:.||:|.||.:....:. ::|.||...:.:..|.
  Fly   406 TLQDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQ-QDFKREIELISDLKHQ 469

Human   579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGM 643
            ::..::||.|...     |..| :..:|.:||||.||:::...|.. :|.....::..:.|:.||
  Fly   470 NIVCILGVVLNKE-----PYCM-LFEYMANGDLHEFLISNSPTEGK-SLSQLEFLQIALQISEGM 527

Human   644 EYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNL 708
            :|||:.:::|||||||||::.|.:.|.::||||||.|||.||||....|.|||:|:..||:....
  Fly   528 QYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGK 592

Human   709 YTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADP 773
            :|.:||||:|||.:|||.:.|..||.|..|.|:.|.:.....|..|..|...||.||.:||....
  Fly   593 FTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQS 657

Human   774 KQRPSFTCLRMELE 787
            .:||:||.:...|:
  Fly   658 VKRPTFTDISNRLK 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	Ig1_Tyro3_like	50..136	CDD:409553
		Ig strand A	50..55	CDD:409553
		Ig strand B	58..67	CDD:409553
		Ig strand C	73..78	CDD:409553
		Ig strand C'	81..83	CDD:409553
		Ig strand D	87..92	CDD:409553
		Ig strand E	97..104	CDD:409553
		Ig strand F	113..119	CDD:409553
		Ig strand G	125..136	CDD:409553
		IgI_2_Axl_Tyro3_like	140..220	CDD:409407
		Ig strand A	140..143	CDD:409407
		Ig strand A'	146..150	CDD:409407
		Ig strand B	154..163	CDD:409407
		Ig strand C	168..175	CDD:409407
		Ig strand C'	177..180	CDD:409407
		Ig strand E	184..195	CDD:409407
		Ig strand F	198..207	CDD:409407
		Ig strand G	211..220	CDD:409407
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:394996	1/1 (100%)
		PTKc_Tyro3	508..791	CDD:270659	106/287 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	851..871
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568
		KR	235..312	CDD:214527	7/23 (30%)
		PTKc_Ror	404..673	CDD:270642	104/276 (38%)