DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and Ror

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	134/404 - (33%)
Similarity:	205/404 - (50%)	Gaps:	42/404 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   404 PWSQPLVVSSHDRAGQ--QGPPHSRTSWVPVVLGVLTA--LVTAAALALILLRKRRKETRFGQAF 464
            ||.  .|.||.:|..:  ..|..:...|:.:| |...|  |:.....|:||.::|
  Fly   290 PWC--FVDSSRERIIELCDIPKCADKIWIAIV-GTTAAIILIFIIIFAIILFKRR---------- 341

Human   465 DSVMARGEPAVHFRAARSF------NRERPERIEATLDSLG-ISDE--LKEKL--EDVLIPEQQF 518
             ::|..|...:|.....|.      |.:.....:|...:|| :||.  |..||  .:.|:....|
  Fly   342 -TIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKLIERNTLLRINHF 405

Human   519 TLGRM-----LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
            ||..:     ||:|.||.|.:.||.|.:.:.:.||:|.||.:....:. ::|.||...:.:..|.
  Fly   406 TLQDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQ-QDFKREIELISDLKHQ 469

Human   579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGM 643
            ::..::||.|...     |..| :..:|.:||||.||:::...|.. :|.....::..:.|:.||
  Fly   470 NIVCILGVVLNKE-----PYCM-LFEYMANGDLHEFLISNSPTEGK-SLSQLEFLQIALQISEGM 527

Human   644 EYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNL 708
            :|||:.:::|||||||||::.|.:.|.::||||||.|||.||||....|.|||:|:..||:....
  Fly   528 QYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGK 592

Human   709 YTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADP 773
            :|.:||||:|||.:|||.:.|..||.|..|.|:.|.:.....|..|..|...||.||.:||....
  Fly   593 FTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQS 657

Human   774 KQRPSFTCLRMELE 787
            .:||:||.:...|:
  Fly   658 VKRPTFTDISNRLK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653
		IGc2	56..121	CDD:197706
		Ig2_Tyro3_like	141..220	CDD:143226
		IG_like	145..220	CDD:214653
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:278470	1/1 (100%)
		PTKc_Tyro3	508..791	CDD:270659	106/287 (37%)
		Pkinase_Tyr	518..786	CDD:285015	103/272 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568
		KR	235..312	CDD:214527	7/23 (30%)
		PTKc_Ror	404..673	CDD:270642	104/276 (38%)
		Pkinase_Tyr	410..670	CDD:285015	100/267 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910