DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and Btk29A

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	852	Identity:	211/852 - (24%)
Similarity:	323/852 - (37%)	Gaps:	259/852 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    77 VKDGAVVQNLD--QLYIPVSEQH-W-------IGFLSLKSVE-RSDAGRYWCQ----VEDGGETE 126
            ||.|::|:...  :.:.||:.:| |       ..:..:::|| |.:.||...:    ||:.
  Fly    43 VKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEA---- 103

Human   127 ISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLN 191
                   ||.|      |..|...|...|||:                 |..:|...|.|..:.|
  Fly   104 -------TVSG------EGGDPFAPDGYPFQV-----------------GYCEISASANSHQLEN 138

Human   192 VTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQ 256
            ..|.....       .::|..|.|       |:|  .:.:.|...|....| .|:     ||:.|
  Fly   139 GNGGGSGV-------GIEGQQSGR-------AVP--QYTLYVIANSEKERS-EWI-----RAIRQ 181

Human   257 SCTVQVTQA-----PGGWEVLAVVVPVPPFTC---LLRDLVPATNYSLRV----RCAN---ALGP 306
            .|....|..     ||.|.       ...::|   |.|     |.:..|.    |.||   :.|.
  Fly   182 VCEDSNTPKSYRYHPGLWS-------GKKWSCCKGLSR-----TTFGCRAAAHWREANNNPSNGS 234

Human   307 SPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLG--------------- 356
            ||..:    .|:.::|.|:       .|:|...|:...   ...|.|.:|
  Fly   235 SPAQN----STRSISPNSS-------TTNSQFSLQHNS---SGSLGGGVGGGLGGGGSLGLGGGG 285

Human   357 -------PYKLSWVQDNGTQDELTV----------EGT--RANLTGWDP--------QKD----- 389
                   |..|.      .|..||.          .||  .||:.|..|        .||
  Fly   286 GGGGSCTPTSLQ------PQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFV 344

Human   390 -LIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSW--VPVVLGVLTALVTAAALALILL 451
             |:|.:....|:..|.      :|....|..:....|:..|  |...||.:..:.:.......||
  Fly   345 KLVVALYPFKAIEGGD------LSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALL 403

Human   452 RKRRKETRFG----QAFDSVMARGEP-----------------AVHFRAARS----FNRERPERI 491
            ...|.|...|    |..:|::.:|:.                 ::|.:..:|    ::.::..|.
  Fly   404 GLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARC 468

Human   492 EATL------------------DSLGISDELKEKLEDVLIP-------------EQQFTLGRMLG 525
            |..|                  :|.|::..||....|..:|             ..:..|...||
  Fly   469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELG 533

Human   526 KGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRS 590
            .|:||.||..:.:   || :..||||:|...::..|   |:.||..|.:..||::.:|.||..:.
  Fly   534 SGQFGVVRRGKWR---GS-IDTAVKMMKEGTMSEDD---FIEEAKVMTKLQHPNLVQLYGVCSKH 591

Human   591 RAKGRLPIPMVILPFMKHGDL------HAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSR 649
            |     || .::..:||||.|      |...|...:|         .|:...:.::.||.||...
  Fly   592 R-----PI-YIVTEYMKHGSLLNYLRRHEKTLIGNMG---------LLLDMCIQVSKGMTYLERH 641

Human   650 NFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSD 714
            |:||||||||||::..:..|.||||||:|.:....|...| .:|.|:||...|.|....::.:||
  Fly   642 NYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSG-GTKFPIKWAPPEVLNYTRFSSKSD 705

Human   715 VWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF 779
            |||:||.||||.|.|:.||..::|.|:...:..|..|::|..|.:::||:|..|||..|::||:|
  Fly   706 VWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770

Human   780 TCLRMEL 786
            ..|..:|
  Fly   771 RVLMDQL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	15/72 (21%)
		IGc2	56..121	CDD:197706	14/58 (24%)
		Ig2_Tyro3_like	141..220	CDD:143226	15/78 (19%)
		IG_like	145..220	CDD:214653	14/74 (19%)
		FN3	225..317	CDD:238020	24/106 (23%)
		fn3	324..406	CDD:278470	24/129 (19%)
		PTKc_Tyro3	508..791	CDD:270659	103/298 (35%)
		Pkinase_Tyr	518..786	CDD:285015	100/273 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	51/245 (21%)
		SH3_Tec_like	346..399	CDD:212702	11/58 (19%)
		SH2_Tec_family	403..505	CDD:198188	16/101 (16%)
		PTKc_Tec_like	521..778	CDD:173637	101/280 (36%)
		Pkinase_Tyr	526..777	CDD:285015	100/273 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910