DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and DIP-iota

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	186	Identity:	49/186 - (26%)
Similarity:	81/186 - (43%)	Gaps:	24/186 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    55 SQGQPVKLNCSVEGMEEPDIQWVKDGA----VVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRY 115
            |.||.|.|.||..|:..|.|.|.::.|    :..:.|:....|..|:    |:|..|:||..|.|
  Fly   147 STGQNVTLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQN----LTLWQVQRSHMGAY 207

Human   116 WCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI 180
            .|...:|....:|:.|.|.|...|  |:..:...:......:|:.|.:...:|.::.:|...:::
  Fly   208 LCIASNGVPPTVSKRVMLVVNFAP--TIWTRYDTIYVGLGQKLTLECITESQPASVNFWLRDSQL 270

Human   181 --GGPAPSPSV---------LNVTGVTQSTM--FSCEAHNLKGLASSRTATVHLQA 223
              ||...|.||         :.:..:|:...  :.|.|.|..| .:.|..|||.:|
  Fly   271 LQGGSYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMG-QTDRIITVHHKA 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	27/83 (33%)
		IGc2	56..121	CDD:197706	22/68 (32%)
		Ig2_Tyro3_like	141..220	CDD:143226	17/91 (19%)
		IG_like	145..220	CDD:214653	16/87 (18%)
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653
		Ig	39..122	CDD:299845
		Ig	132..213	CDD:299845	23/69 (33%)
		IG_like	141..227	CDD:214653	27/83 (33%)
		IG_like	239..322	CDD:214653	16/83 (19%)
		IGc2	245..313	CDD:197706	13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910