DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and bdl

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	103/380 - (27%)
Similarity:	152/380 - (40%)	Gaps:	62/380 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    24 GLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEP--DIQWVKDGAVVQNL 86
            |.|..|.|.|.:...|    |::.||.::.:..|||..|:|.... ..|  :::|.|||.:   .
  Fly   231 GELQTAKAFLNIQYKA----KVIYAPPEVFLPYGQPAVLDCHFRA-NPPLKNLRWEKDGLL---F 287

Human    87 DQLYIPVSEQHWIGFLSLKSVERSDAGRYWC-QVEDGGETEISQPVWLTVEGVPFFTVEPKDLAV 150
            |...:|.......|.|....|:.:.||.|.| ...|.|....|..:.:.|...|.|:|.||.:.:
  Fly   288 DSYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYI 352

Human   151 PP-NAPFQLSCEAV---GPPEPVTIVWWRGTTKIGGPAP------SPSVLNVTGVTQST--MFSC 203
            .. ....:|.|||:   |...| :|:|.|   |.|.|.|      |...|.:||:.:..  ::.|
  Fly   353 QKLGEAAELPCEAIDRDGNNRP-SIIWGR---KDGQPLPADRFSLSGGNLTITGLVEGDRGIYEC 413

Human   204 EAHNLKGLASSRTATVHL---QALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQA 265
            .|.|   .|::.||...|   ...|.||:|:|... :.:..::.|.||.....|..:...::.:|
  Fly   414 SATN---EAATITAEAELMIENIAPRAPYNLTANS-TETCITIRWQPGYLRPNLEYTVWYRLMEA 474

Human   266 PGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQT------------- 317
            | .|..|. |:........::.|.|...|...|...:..|...::....|||
  Fly   475 P-EWRTLR-VLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQ 537

Human   318 -------KGLAPA---SAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSW 362
                   :..|||   .||.||.||....|.:|.||.  |...||| |..|.:.|
  Fly   538 QLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEH--PVQGLEG-LRLYAVRW 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	23/88 (26%)
		IGc2	56..121	CDD:197706	19/67 (28%)
		Ig2_Tyro3_like	141..220	CDD:143226	27/90 (30%)
		IG_like	145..220	CDD:214653	25/86 (29%)
		FN3	225..317	CDD:238020	20/91 (22%)
		fn3	324..406	CDD:278470	17/39 (44%)
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	5/10 (50%)
		Ig	157..242	CDD:299845	5/10 (50%)
		Ig_2	252..337	CDD:290606	23/88 (26%)
		IG_like	260..327	CDD:214653	21/70 (30%)
		I-set	341..428	CDD:254352	28/93 (30%)
		IGc2	356..419	CDD:197706	20/69 (29%)
		FN3	435..524	CDD:238020	20/91 (22%)
		FN3	554..636	CDD:238020	17/39 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910