DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and dpr2

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001014480.4	Gene:	dpr2 / 3346227	FlyBaseID:	FBgn0261871	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	226	Identity:	53/226 - (23%)
Similarity:	88/226 - (38%)	Gaps:	50/226 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    47 GAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKD--------GAVVQNLDQLYIPV---SEQHWIG 100
            |.|..:|...|....:||.|:.:.:..:.|::.        |.:....|:.:..|   ..:.|.
  Fly   111 GMPRNITTRTGHTAAINCRVDNLGDKSVSWIRKRDLHILTAGILTYTSDERFKVVRTADSKDWT- 174

Human   101 FLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVP----FFTVEPKDLAVPPNAPFQLSC- 160
             |.:|..:..|:|.|.|||..  |.:||....|.|...|    .....|.||.|...:...|:|
  Fly   175 -LHVKYAQPRDSGIYECQVNT--EPKISMAFRLNVIVTPPDAKAIIAGPTDLYVKVGSSVTLTCH 236

Human   161 --------EAVGPPEPVTIVWWRG----TTKIGGPAPSPSVLNVTGVT-QSTMFSCEAHNLKGLA 212
                    :.:||     |.|:||    |..:.  .|:.:.:::..:: :||:    |..|:
  Fly   237 VKQPATSAQDIGP-----IYWYRGPYILTPFVA--HPNDAAIDLQRISMESTL----AEKLQ--- 287

Human   213 SSRTATVHLQALPAAPFNITVTKLSSSNASV 243
             ||....:.|.|...  |.|....::..|||
  Fly   288 -SRLRIANAQLLDTG--NYTCMPTTAEAASV 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	23/96 (24%)
		IGc2	56..121	CDD:197706	17/75 (23%)
		Ig2_Tyro3_like	141..220	CDD:143226	20/92 (22%)
		IG_like	145..220	CDD:214653	20/88 (23%)
		FN3	225..317	CDD:238020	5/19 (26%)
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
dpr2	NP_001014480.4	IG_like	113..206	CDD:214653	23/96 (24%)
		Ig	116..192	CDD:299845	16/77 (21%)
		ig	220..306	CDD:278476	24/102 (24%)
		IG_like	220..306	CDD:214653	24/102 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910