DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYRO3 and dpr4

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster

Alignment Length:	211	Identity:	50/211 - (23%)
Similarity:	88/211 - (41%)	Gaps:	45/211 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    51 KLTVSQGQPVKLNCSVEGMEEPDIQWVKD--------GAVVQNLDQLYIPVSEQ---HWIGFLSL 104
            ::|.:.||...|:|.|..:.:..:.|::.        |.:....||.:..:..:   .|.  |.:
  Fly    54 EVTATVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWT--LRI 116

Human   105 KSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPV 169
            .|.:..|:|.|.|||..  |.:|||...|.|.......:...:|.:...:...|:|.|:..|.|.
  Fly   117 SSPQPRDSGTYECQVST--EPKISQGFRLNVVVSRAKILGNAELFIKSGSDINLTCLAMQSPVPP 179

Human   170 TIVWWRGTTKI------GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHL-QALPAA 227
            :.::|....::      ||       :||  :|:              .|:||:.:.: :|.||.
  Fly   180 SFIYWYKGKRVMNYSQRGG-------INV--ITE--------------RSTRTSKLLIAKATPAD 221

Human   228 PFNITVTKLSSSNASV 243
            ..|.|.:..||.:|||
  Fly   222 SGNYTCSPSSSDSASV 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	24/94 (26%)
		IGc2	56..121	CDD:197706	18/75 (24%)
		Ig2_Tyro3_like	141..220	CDD:143226	15/84 (18%)
		IG_like	145..220	CDD:214653	15/80 (19%)
		FN3	225..317	CDD:238020	9/19 (47%)
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	24/95 (25%)
		IG_like	53..145	CDD:214653	24/94 (26%)
		ig	153..227	CDD:278476	19/96 (20%)
		IG_like	161..>227	CDD:214653	18/88 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910