DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and dpr18

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	95	Identity:	27/95 - (28%)
Similarity:	38/95 - (40%)	Gaps:	21/95 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    38 SAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKD----------GAVVQNLDQLYIP 92
            ||.:|..|:.|....|     ...|||.|..:::..:.||:.          |.|..:.|. .|.
  Fly   225 SATSGDNLVSAVHLFT-----EAVLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTYSGDP-RIR 283

Human    93 VSEQH---WIGFLSLKSVERSDAGRYWCQV 119
            |..|:   |  .|.:...:..|||.|.|||
  Fly   284 VKFQYPNNW--RLLINPTQTEDAGVYMCQV 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	22/84 (26%)
		IGc2	56..121	CDD:197706	21/77 (27%)
		Ig2_Tyro3_like	141..220	CDD:143226
		IG_like	145..220	CDD:214653
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	21/73 (29%)
		Ig	<258..326	CDD:299845	17/57 (30%)
		IGc2	<417..461	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910