DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and DIP-kappa

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	53/193 - (27%)
Similarity:	86/193 - (44%)	Gaps:	31/193 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    52 LTVSQGQPVKLNCSVEGMEEPDIQWVK-DGAVVQNLDQLYIPVSEQ-------HWIGFLSLKSVE 108
            :|||.|:...:.|.||.::...:.||: |...:.::....|..:.:       |...:|.:|.||
  Fly    83 VTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRSWYLHIKEVE 147

Human   109 RSDAGRYWCQVEDG------GETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPE 167
            .:|.|.|.|||...      |..::..|. :.|||     :...|:.|.......|.|:|.|.||
  Fly   148 ETDRGWYMCQVNTDPMRSRKGYLQVVVPP-IIVEG-----LTSNDMVVREGQNISLVCKARGYPE 206

Human   168 PVTIVWWRGTTK---IGGP---APSPSVLNVTGVTQSTM--FSCEAHNLKGLASSRTATVHLQ 222
            |. ::|.|...:   |||.   .....:|::|.|::..|  :.|.|.|  |:..|.:..|||:
  Fly   207 PY-VMWRREDGEEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASN--GVPPSISKRVHLR 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	24/96 (25%)
		IGc2	56..121	CDD:197706	19/72 (26%)
		Ig2_Tyro3_like	141..220	CDD:143226	23/86 (27%)
		IG_like	145..220	CDD:214653	23/82 (28%)
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	23/88 (26%)
		IG_like	82..174	CDD:214653	23/90 (26%)
		IG_like	184..267	CDD:214653	26/86 (30%)
		IGc2	191..255	CDD:197706	19/66 (29%)
		IG_like	282..368	CDD:214653
		Ig	288..367	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910