DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TYRO3 and Wsck

DIOPT Version :9

Sequence 1:NP_006284.2 Gene:TYRO3 / 7301 HGNCID:12446 Length:890 Species:Homo sapiens
Sequence 2:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster


Alignment Length:873 Identity:186/873 - (21%)
Similarity:302/873 - (34%) Gaps:279/873 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   130 PVWLTVEGVPFFTVEPKDLAVPPNAP--FQLSC---------EAVGPPEPVTIVWWRGTTKIGGP 183
            |:||:...|......|...|||..||  :.:.|         |:|....|.|.:           
  Fly    13 PIWLSSCLVAMCLGLPLGAAVPQEAPAYYYVGCYTARTDLLHESVYAKTPQTCI----------- 66

Human   184 APSPSVLNVTGVTQSTMFS--CEAHNL--------KGLASSRTAT----------VH------LQ 222
                .:....|...:.:.|  |...|:        :.|.::|...          ||      |.
  Fly    67 ----EICEHQGHHYAVLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILT 127

Human   223 ALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWE------------VLAVV 275
            ..| .|.::.::..:.::.:::| ...:.|.||.:         ||.|            :.|.|
  Fly   128 KQP-GPHHLRISNKTENSLTLSW-NAYEARKLLLA---------GGAEAVLPNQLLDNFLIKAQV 181

Human   276 V---------PVPPFTCL-------LRDLVPATNYSLRVR------------CANA-------LG 305
            :         |.|.|...       |.||.|||.|::.||            |..|       :|
  Fly   182 LKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVG 246

Human   306 -PSPYADWVPFQTKGLA--PASAPQNLHAIRTDSG------LILEWEEVIPEAPLEGP-LGPYKL 360
             |||    ||.|.|.|:  ..:....|..||.|:|      :|:|:.:.....|.:.. ||    
  Fly   247 LPSP----VPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLG---- 303

Human   361 SWVQ--------------------DNGTQDELTVEGTRANLTGWDP--QKDLIVRV---CVSNAV 400
            ||.|                    ||.|:..:..:|.|.......|  |.|..|.:   .||...
  Fly   304 SWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLE 368

Human   401 GC-------GPWSQPLVVSSHD------RAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILL- 451
            |.       |...|. |.|..|      ..||..          ||...:|.::..:.|.|.|: 
  Fly   369 GVTKTMYSRGTHDQH-VTSLDDFSYATFEKGQSS----------VVALAVTCVIFGSCLLLSLIA 422

Human   452 ---------RKRR-----------------KETRFGQAFDSVMARGEPAVHFRAARSFNRERPER 490
                     |.||                 :|.      :..:...:|..|          .||.
  Fly   423 YFYLRYKTCRGRRLTGGNTHEMTLQTPIIEREN------NGYLVEDDPLPH----------SPEN 471

Human   491 IEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVK-VAVKMLKA 554
            .:..|      .:|.|..|.:.....:..:..::|.|.||.:...::...|  |.: ..:.:|..
  Fly   472 FKQQL------QQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTND--FARDCTLHVLCL 528

Human   555 DIIASSDIEEFLREAACMKEFD-HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLAS 618
            |.:..:...:.|||...:.:.. ..|:....|||..       |....::...:...|...|:.|
  Fly   529 DDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSAS-------PDWFYLIFEQQRMSLKRKLVES 586

Human   619 RI-GENP--FNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFG----- 675
            |: ..:|  .:|..|.:::::.::|..|.||||...:||.|.:.:..:..|..:.::.||     
  Fly   587 RLMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYM 651

Human   676 -LSRKIYSGDYYRQGCASKLPVKWLALESLA-DNLYTVQSDVWAFGVTMWEIMTRGQTPYAG--I 736
             ::|:  ..|:.|          |||.|.|. .:.::.:||||:.....||....|.||||.  .
  Fly   652 NIARQ--QPDHNR----------WLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVA 704

Human   737 ENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENI-LGQLSVLSASQ 800
            .|.::...:....|..||.....|:|.|:..||..:|.:|.|  |     |:: .|...::::.:
  Fly   705 SNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSS--C-----EDVAFGVRQLMTSPR 762

Human   801 DPLYINIERAEEPTAGGSLELPGRDQPY 828
            ..|  :.:|    .|||...||    ||
  Fly   763 HAL--SFDR----VAGGLDTLP----PY 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TYRO3NP_006284.2 IG_like 49..135 CDD:214653 3/4 (75%)
IGc2 56..121 CDD:197706
Ig2_Tyro3_like 141..220 CDD:143226 17/109 (16%)
IG_like 145..220 CDD:214653 17/105 (16%)
FN3 225..317 CDD:238020 31/139 (22%)
fn3 324..406 CDD:278470 26/120 (22%)
PTKc_Tyro3 508..791 CDD:270659 69/297 (23%)
Pkinase_Tyr 518..786 CDD:285015 67/281 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..837 7/14 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..871
WsckNP_733018.1 WSC 42..115 CDD:280068 11/87 (13%)
fn3 130..222 CDD:278470 22/102 (22%)
TyrKc 493..746 CDD:197581 65/273 (24%)
PTKc 497..750 CDD:270623 68/280 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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