DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and dpr14

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001245573.1	Gene:	dpr14 / 31702	FlyBaseID:	FBgn0029974	Length:	340	Species:	Drosophila melanogaster

Alignment Length:	192	Identity:	43/192 - (22%)
Similarity:	66/192 - (34%)	Gaps:	50/192 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    50 VKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVE------ 108
            :.::......|.|:|.|..::...:.|::     :..|.|.:....||.....|..|:|
  Fly    82 LNISTQLSSSVYLHCRVNDLQGKTVSWMR-----RRGDDLTLITFGQHTYSGDSRYSLEFEEPND 141

Human   109 ---------RSDAGRYWCQVEDGGETEISQP-----VWLTVEGVPFFTV-EPKDLAVP-----PN 153
                     ..|.|.|.|||.       |.|     |:||:. ||...: :.:..|.|     ..
  Fly   142 WKLLIQFANERDEGPYECQVS-------SHPPLVLLVYLTII-VPHVEILDERGSATPEKYYKAG 198

Human   154 APFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSR 215
            :..:|.|.....|.|.:.:.||         ..|.:||..  |.....|.:...|.|.|.||
  Fly   199 STIELQCVISKIPHPSSYITWR---------HGPRLLNYD--TSRGGISVKTDMLPGRALSR 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	22/104 (21%)
		IGc2	56..121	CDD:197706	18/79 (23%)
		Ig2_Tyro3_like	141..220	CDD:143226	18/81 (22%)
		IG_like	145..220	CDD:214653	18/76 (24%)
		FN3	225..317	CDD:238020
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
dpr14	NP_001245573.1	IG_like	83..163	CDD:214653	18/91 (20%)
		Ig	84..169	CDD:299845	20/96 (21%)
		IG_like	191..279	CDD:214653	17/70 (24%)
		Ig	201..274	CDD:143165	16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910