DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYRO3 and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_006284.2	Gene:	TYRO3 / 7301	HGNCID:	12446	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	68/296 - (22%)
Similarity:	122/296 - (41%)	Gaps:	58/296 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    52 LTVSQGQPVKLNCSVEGMEEPDIQWVK-DGAVVQNLDQLYIP----VSEQH-----WIGFLSLKS 106
            ::|:.|:.....|.|..:....:.|:| |...:|.:.:..|.    |:..|     |  .|.:|:
  Fly    51 VSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTW--NLHIKA 113

Human   107 VERSDAGRYWCQVE-DGGETEISQPVWLTVEGVPFFTVE--PKDLAVPPNAPFQLSCEAVGPPEP 168
            |...|.|.|.||:. |..:::|.   :|.|...|.|..|  ..|:.||..:..:|:|.|.|.|||
  Fly   114 VSEEDRGGYMCQLNTDPMKSQIG---FLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEP 175

Human   169 VTIVWWRGT------------TKIGGPAPSPSVLNVTGVTQSTM--FSCEAHNLKGLASSRTATV 219
              ||.||..            ||...|:....||.::.::::.|  :.|.|.|  |:..|.:..:
  Fly   176 --IVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASN--GVPPSVSKRI 236

Human   220 HL-----------QALPAAPFNITV---TKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGG-W 269
            .|           ..|..||....|   ..:.:|..|:.:.....|..::.|....|.::... :
  Fly   237 SLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMY 301

Human   270 EV-LAVVV------PVPPFTCLLRDLVPATNYSLRV 298
            |. ::::|      .|..:.|:.::.:...:.|:|:
  Fly   302 ETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYRO3	NP_006284.2	IG_like	49..135	CDD:214653	23/93 (25%)
		IGc2	56..121	CDD:197706	19/75 (25%)
		Ig2_Tyro3_like	141..220	CDD:143226	27/94 (29%)
		IG_like	145..220	CDD:214653	25/88 (28%)
		FN3	225..317	CDD:238020	14/85 (16%)
		fn3	324..406	CDD:278470
		PTKc_Tyro3	508..791	CDD:270659
		Pkinase_Tyr	518..786	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..871
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	20/79 (25%)
		Ig	51..131	CDD:299845	21/81 (26%)
		I-set	144..240	CDD:254352	29/99 (29%)
		IGc2	159..228	CDD:197706	20/72 (28%)
		Ig	244..337	CDD:299845	14/92 (15%)
		I-set	244..337	CDD:254352	14/92 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910