DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYK2 and Tyk2

DIOPT Version :9

Sequence 1:	NP_001372133.1	Gene:	TYK2 / 7297	HGNCID:	12440	Length:	1257	Species:	Homo sapiens
Sequence 2:	NP_001192241.1	Gene:	Tyk2 / 54721	MGIID:	1929470	Length:	1207	Species:	Mus musculus

Alignment Length:	1270	Identity:	939/1270 - (73%)
Similarity:	1023/1270 - (80%)	Gaps:	103/1270 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    12 SKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFAL 76
            ||..|..|||:...|.|.|||||.||.|||||||||::|||||||||||||||||||||.|||||
Mouse    17 SKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFAL 81

Human    77 FDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGM 141
            ::|||:|||||||||:..:|  :.||||:||||||||||||:||||||||.||.|.|||:..||:
Mouse    82 YNAQAKVWLPPNHILDTSQD--MNLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETSSDRAEQGV 144

Human   142 QLLDPASFEYLFE-----------------------QGKHEFVNDVASLWELSTEEEIHHFKNES 183
            ||||.||||||||                       ||||||:|||.||.:||:|||||||||||
Mouse   145 QLLDSASFEYLFEQGWYVGNRAKSSHTSFSIHRSTPQGKHEFMNDVVSLRDLSSEEEIHHFKNES 209

Human   184 LGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPG 248
            |||||||||||||..|:||||:|::.|||:|||.|||:|||||:.||||||..|||||||.|:||
Mouse   210 LGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFRPG 274

Human   249 RLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPT 313
            .||||:|||||||||||||||||:||:|||||.:|||.|.:||||::||....|||||..:||||
Mouse   275 HLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDPGPELPSGPPT 339

Human   314 HEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFC 378
            |||||||||||||.|::    .:|...|:|..||..|..|||.||.||.....:.|:||.|.|||
Mouse   340 HEVLVTGTGGIQWHPLQ----TQESERGNSRGNPHGSRSGKKPKAPKAGEHLTESPQEPPWTYFC 400

Human   379 DFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRL 443
            ||:||:||||||..|.||.||||||.|.|.|:|.|||||:|||||||||||||||||||||||||
Mouse   401 DFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRL 465

Human   444 VMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQA-PDGMQSLRLRKFPI 507
            |.||::||||||::|||||||.||||||||.|||||.:|||||||.|:.| .:|.:.||||||||
Mouse   466 VTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPI 530

Human   508 EQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPR 572
            .||.|||||:||||||.|:.:|..|||||.||||||||.|..||||:|.|.|||:||||:||..|
Mouse   531 TQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTR 595

Human   573 TLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQEL 637
            .|||||||||||.|.|||||||||||||||||||.|||   |.|:|||:|:..|..||...||:|
Mouse   596 PLNLSQLSFHRVHQDEITQLSHLGQGTRTNVYEGLLRV---GGPDEGKVDNGCPPEPGGTSGQQL 657

Human   638 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRE 702
            ||||||||||||||||||||||||||||||.||||:|||||||.|||:|||:||||||||||||:
Mouse   658 RVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQ 722

Human   703 RGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGAL 767
            ||.|||.|||||||||||||||||:||||||||||||||||||||.|||:|||||||||||.|||
Mouse   723 RGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGAL 787

Human   768 SREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCLGDPWALP 832
            |||||||||||.|||||.||.:||.||.|.|||||||||||||||||||.|.|||
Mouse   788 SREERVERIPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSE---------- 842

Human   833 AVGAPPRNPEDRIRAQSCIPSGLVTSSLSGLPAGGPLAGAQCSPSLFRSLWKSLVPGTQKKEHFY 897
                                                                        ||.||
Mouse   843 ------------------------------------------------------------KERFY 847

Human   898 QRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVF 962
            .::|:|||||.|:|||||.|||||||.|||||||||||||||||.||.....||.||||||||||
Mouse   848 TKKHQLPEPSSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVF 912

Human   963 HKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE 1027
            |||||||||||||||||||||||||||||||||||||||||..||||.||||::||:||||||||
Mouse   913 HKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHE 977

Human  1028 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHR 1092
            ||:|||||||||||||:|||||||||||||||||||.:|||||||||||||||||||||||||||
Mouse   978 HIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHR 1042

Human  1093 DLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSF 1157
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
Mouse  1043 DLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSF 1107

Human  1158 GVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCW 1222
            |||||||||:|||:|||..||.||||..|||||||||||||||||||||||:||||:||||||||
Mouse  1108 GVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCW 1172

Human  1223 ETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 1257
            ||||||||||:||:|||:|..||||||.|||||||
Mouse  1173 ETEASFRPTFQNLVPILQTAQEKYQGQVPSVFSVC 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYK2	NP_001372133.1	FERM_F1	28..125	CDD:408179	77/96 (80%)
		FERM_F2	143..266	CDD:408177	98/145 (68%)
		Jak1_Phl	285..432	CDD:407742	91/146 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..366		13/30 (43%)
		SH2	437..534	CDD:417686	70/97 (72%)
		PKc_like	589..937	CDD:419665	231/347 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..629		8/18 (44%)
		PTKc_Tyk2_rpt2	962..1244	CDD:270664	257/281 (91%)
Tyk2	NP_001192241.1	B41	45..299	CDD:214604	185/255 (73%)
		PH-like	296..459	CDD:302622	107/166 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..391		41/77 (53%)
		SH2	459..557	CDD:301589	70/97 (72%)
		PKc_like	612..887	CDD:304357	231/347 (67%)
		Pkinase_Tyr	612..886	CDD:285015	230/346 (66%)
		PTKc_Tyk2_rpt2	912..1194	CDD:270664	257/281 (91%)
		TyrKc	917..1189	CDD:197581	249/271 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83953166
Domainoid	1	1.000	534	1.000	Domainoid score	I6591
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20712
Inparanoid	1	1.050	1926	1.000	Inparanoid score	I1762
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D31031at32523
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		oto121784
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR45807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410