DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TYK2 and hop

DIOPT Version :9

Sequence 1:NP_001372133.1 Gene:TYK2 / 7297 HGNCID:12440 Length:1257 Species:Homo sapiens
Sequence 2:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster


Alignment Length:1326 Identity:296/1326 - (22%)
Similarity:492/1326 - (37%) Gaps:344/1326 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    50 SLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQ-----------VWLPPNHILEIPRDASLMLYF 103
            ::..||:|..:..::||.|....|:.:.:....           .|..|...|    :..|:..|
  Fly    64 NMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERL----NCQLVYCF 124

Human   104 RIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLW 168
            |:||          |.|          |..|.     ::|:|..|.::|:.|.:          :
  Fly   125 RMRF----------RVP----------ELDSQ-----LELIDGRSHKFLYRQMR----------Y 154

Human   169 ELSTEE--EIHH--FKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHI-----R 224
            ::.||:  ||.:  .|::|.|:|.:.:.       |..:|.::.......|.:.::.::     |
  Fly   155 DMRTEQIPEIRYPEHKDKSTGLAVMDML-------IDDQEQSEDQQAMRSIEKLYKLYLPPSLWR 212

Human   225 QHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGE 289
            .||.....::|.||    |..:...||.:.:...|:..:..|||.:.||:. .|.::.|...|  
  Fly   213 AHSFFVGSKIREVF----RSLKANSLSVERLKWHYVHQVSHLAPTYMTEQF-TCTVQYLPNEE-- 270

Human   290 PCYIRDSG-----VAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQA 349
              ..|.||     :|.:.....|:....|...|.|.|..:              :.|.|      
  Fly   271 --VARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSV--------------ALGGS------ 313

Human   350 SLFGKKAKAHKAVGQ--------PADRPREPL------------WAYFCDFRDITHVVLKEHCVS 394
               |||||.....|.        |.|.....|            |........| .::.|.:..|
  Fly   314 ---GKKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEGI-FMISKINDTS 374

Human   395 IHRQD---NKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLL 456
            :..:.   .|..|:...:.....||:|.:..|.||::.....|||....|.|........|||:.
  Fly   375 VRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIG 439

Human   457 EPFVQAKLRPED---GLYLIHWSTSHPYRLIL------TVAQRSQAPDGMQSLRLRKFPIEQQDG 512
            ..:...||....   |.|::. .....|.:..      .:|:::.    .:..:...|.|.::|.
  Fly   440 GAYSLMKLHENGDKCGSYIVR-ECDREYNIYYIDINTKIMAKKTD----QERCKTETFRIVRKDS 499

Human   513 AFVLEGWGRSF-------PSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARAS 570
            .     |..|:       .|:.|:...:|.    ...|.:.:......:| ....|::.:..:|.
  Fly   500 Q-----WKLSYNNGEHVLNSLHEVAHIIQA----DSPDRYRIPASKYDKP-PLLLLLLPKNLKAK 554

Human   571 PRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNV--YEGRLRVEGSG--DPEEGKMDDEDPLVPGR 631
            ...|.||:....|.:.:..        ..||::  |...:.:...|  ....|....:.|:    
  Fly   555 KTDLQLSEAELQRRNPQIF--------NPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPV---- 607

Human   632 DRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696
               :::.|.:|:|....:  .:.|:..|...|.:.......::|:.:..|.. ||.||..:|||:
  Fly   608 ---KDVSVTMKMLKSDGN--FMEFFRLAQTWSLIQSPQFLKLYGLTLADPYT-MVMEYSRYGPLN 666

Human   697 VWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI---KLS 758
            .:| ....:|.:...:.:...|...:.|||:..::|..:...|:.:.:.    ..:.::   |:|
  Fly   667 KFL-HSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKY----DPNSYVLDAKIS 726

Human   759 DPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDK----WGFGATLLEI---CFDGEAPLQ 816
            |||     ..|..|....||:..:..   .|..:...|:    |.|..|:.||   |.:..:.|:
  Fly   727 DPG-----YPRPYRESDSPWIPVKYY---RNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLR 783

Human   817 SRS---------------PSEVC-------LGDPWALPAVGAPPRNPEDRIRAQSCIPSGLVTSS 859
            ...               ..::|       :.|.|:         :.|.:..:...|.|.|.|..
  Fly   784 QEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWS---------DDETKRFSHHDIFSRLNTIK 839

Human   860 LSGLPAGGPLAGAQCSPSLFRS-------LWKSLVPGTQKKEHFYQRQHRLPEPSCPQLAT--LT 915
            ...||...|      .|.:..:       :.:|.:|             .||.|....|..  ||
  Fly   840 AEILPNYMP------PPEIATNGTGDETVIDRSDIP-------------FLPFPRSNMLMVIPLT 885

Human   916 SQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGK 980
            |:|           |.|         :|:.::                         :|.||:|.
  Fly   886 SEC-----------RVI---------YNMENM-------------------------IGRGHYGT 905

Human   981 V---SLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEK 1042
            |   .|...|  .|...|.||:|.|..   .|..:.:.:||.|:|||.|.:|:|:|    ...||
  Fly   906 VYKGHLEFND--KDQPREQVAIKMLNT---MQVSTDFHREIGIMRTLSHPNIVKFK----YWAEK 961

Human  1043 SLQLVMEYVPLGSLRDYL--PRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDND- 1104
            |..::|||:..||...||  ...::...:|:.||..|..||.||.....|||||||||:|:|:: 
  Fly   962 SHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNG 1026

Human  1105 --RLVKIGDFGLAK-AVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT 1166
              ..|||.|||||: |..:|  ||..:...|.|:.||:||.:...:|...|||||:||||:|:.:
  Fly  1027 DGDCVKISDFGLAQFANSDG--YYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFS 1089

Human  1167 HCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPT 1231
            .   .:.|     .|:.|...|...|   ..|:.||||.||..||..:|.||:.||......||:
  Fly  1090 R---GEEP-----NLVPIQTSQEDFL---NRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPS 1143

Human  1232 FENLIPIL------KTVHEKYQGQAP 1251
            |..::.|:      |..|.....|:|
  Fly  1144 FATIVDIITREVATKVTHPTDGHQSP 1169

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TYK2NP_001372133.1 FERM_F1 28..125 CDD:408179 17/85 (20%)
FERM_F2 143..266 CDD:408177 26/131 (20%)
Jak1_Phl 285..432 CDD:407742 33/174 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..366 8/38 (21%)
SH2 437..534 CDD:417686 18/112 (16%)
PKc_like 589..937 CDD:419665 71/392 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..629 3/20 (15%)
PTKc_Tyk2_rpt2 962..1244 CDD:270664 106/296 (36%)
hopNP_511119.2 B41 39..259 CDD:214604 50/244 (20%)
SH2_Jak_family 420..516 CDD:198177 17/105 (16%)
PTK_Jak_rpt1 584..836 CDD:270633 50/283 (18%)
PTKc_Jak_rpt2 886..1155 CDD:270634 110/335 (33%)
TyrKc 894..1151 CDD:197581 104/303 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I3279
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47769
OrthoDB 1 1.010 - - D38412at33208
OrthoFinder 1 1.000 - - FOG0001105
OrthoInspector 1 1.000 - - otm40514
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45807
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X669
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.940

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