DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TYK2 and SPAP27G11.07c

DIOPT Version :9

Sequence 1:	NP_001372133.1	Gene:	TYK2 / 7297	HGNCID:	12440	Length:	1257	Species:	Homo sapiens
Sequence 2:	NP_593411.1	Gene:	SPAP27G11.07c / 2541953	PomBaseID:	SPAP27G11.07c	Length:	238	Species:	Schizosaccharomyces pombe

Alignment Length:	247	Identity:	55/247 - (22%)
Similarity:	86/247 - (34%)	Gaps:	92/247 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   994 GEMVAVKALKADCGPQHRSGWK-----QEIDILRTLYHEHII---KYKGC-C-------EDQGEK 1042
            ||:..:|     |.|..|  |:     |::...|.|....::   .|.|. |       .::|
pombe    42 GEVCLLK-----CRPAKR--WRHPILDQKLSRKRCLVEARLLAKCHYVGIKCPMLYFIDANRG-- 97

Human  1043 SLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICE----------------GMAYLHAQHYIH 1091
              |:.||::....:|||:              ::|||                .:|.:|....:|
pombe    98 --QIYMEWIDGPCVRDYI--------------REICECEIEKKLIPLMKRIGSEVAKMHKNDIVH 146

Human  1092 RDLAARNVLLD--NDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDV 1154
            .||...|::|:  |:.:....||||. :|.|..|        |..|..|..|
pombe   147 GDLTTSNMMLESHNNPVPIFIDFGLG-SVSESEE--------DKAVDIYVLE------------- 189

Human  1155 WSFGVTLYE---LLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 1203
            .:...||.|   |..|...|.:...|        |.:.|:.|..|:..||.:
pombe   190 RALSSTLPESESLFHHVLDSYAQSWK--------QSKATLRRFEEVRMRGRK 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYK2	NP_001372133.1	FERM_F1	28..125	CDD:408179
		FERM_F2	143..266	CDD:408177
		Jak1_Phl	285..432	CDD:407742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..366
		SH2	437..534	CDD:417686
		PKc_like	589..937	CDD:419665
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..629
		PTKc_Tyk2_rpt2	962..1244	CDD:270664	55/247 (22%)
SPAP27G11.07c	NP_593411.1	Bud32	23..238	CDD:226168	55/247 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910